ATF6, activating transcription factor 6, 22926

N. diseases: 179; N. variants: 30
Disease: Huntington Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.040 Biomarker disease BEFREE Our results indicate that DREAM inhibition markedly improves ATF6 processing in the hippocampus and that it might contribute to a delay in memory decline in HD mice. 29523177 2018
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.040 Biomarker disease BEFREE Here we aimed to explore whether ATF5 is also expressed by neurons in human brain both in basal conditions and in Huntington's disease (HD), where UPR has been described to be partially impaired due to defective ATF6 processing. 28861715 2017
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.040 Biomarker disease BEFREE Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease. 26752648 2016
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.040 Biomarker disease BEFREE Our results suggest that the ATF6α/Rheb pathway is altered in Huntington's disease as the decrease in ATF6α processing is accompanied by a decrease in the accumulation of Rheb. 20732420 2011