ATF6, activating transcription factor 6, 22926

N. diseases: 179; N. variants: 30
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.020 Biomarker disease BEFREE Also we found hyperactivation of several genes responsible for ERS such as ATF-4 (p < 0.01), ATF-6 (p < 0.01), EIF2α3K (p < 0.005), CCT4 (p < 0.001), CHOP (p < 0.01), CALR (p < 0.001) and CANX (p < 0.005), that corroborate the idea that diabetes <i>mellitus</i> and metabolic syndrome are associated with direct damage to the endoplasmic reticulum homeostasis. 29449893 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.020 AlteredExpression disease BEFREE Furthermore, PCOS+MetS patients exhibited higher GRP78 and ATF6 levels than controls and PCOS patients without MetS (p<0.05). 28521868 2017