|
Adrenoleukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We used fish which harbor a mutation in the gene encoding the membrane bound transcription factor protease 1 (mbtps1; also called site-1 protease) and embryos in which the Srebp cleavage activating protein (scap) is knocked down to determine the requirement of this pathway in acute ALD.
|
21284674 |
2011 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Xenograft studies reveal that blocking SCAP N-glycosylation ameliorates EGFRvIII-driven glioblastoma growth.
|
26555173 |
2015 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression.
|
31083642 |
2019 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE<sup>-/-</sup> Mice Fed with a High-Fat Diet.
|
28491104 |
2017 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Both SREBP-2 and SCAP are candidates to contribute to the development of atherosclerosis.
|
16466730 |
2006 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE<sup>-/-</sup> mice.
|
30462530 |
2019 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE<sup>-/-</sup> Mice Fed with a High-Fat Diet.
|
28491104 |
2017 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE<sup>-/-</sup> mice.
|
30462530 |
2019 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Both SREBP-2 and SCAP are candidates to contribute to the development of atherosclerosis.
|
16466730 |
2006 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
Meanwhile, SCAP revealed a protective effects on the liver injury-related enzymes and factors, such as significantly diminished malondialdehyde (MDA) levels and glutathione (GSH) depletion, reduced ratio of B-cell lymphoma-2 (Bcl-2)-associated X protein (Bax)/Bcl-2, prohibited cleaved caspase-3 expression, and elevated the expression of p-AMPK, p-Akt, p-glycogen synthase kinase 3β (GSK 3β), nuclear factor erythroid 2-derived-like 2 (Nrf 2) and heme oxygenase-1 (HO-1) proteins in the liver tissues of the mouse model.
|
31400930 |
2019 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, Targeting SCAP may provide a promising means of treating BC and a new perspective for the tumorigenesis of bladder cancer.
|
31360104 |
2019 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Accordingly, targeting of SREBP-2 with Fatostatin which specifically inhibits SCAP (SREBP cleavage-activating protein) and prevents SREBP activation, attenuated breast cancer-induced osteolysis in vivo.
|
30394316 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Thus, Targeting SCAP may provide a promising means of treating BC and a new perspective for the tumorigenesis of bladder cancer.
|
31360104 |
2019 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, Targeting SCAP may provide a promising means of treating BC and a new perspective for the tumorigenesis of bladder cancer.
|
31360104 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Xenograft studies reveal that blocking SCAP N-glycosylation ameliorates EGFRvIII-driven glioblastoma growth.
|
26555173 |
2015 |
|
Chronic Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that ten different polymorphisms were associated (P<0.05) with the prevalence of CKD in high- or low-risk subjects: the -519Aright curved arrow G polymorphism of MMP1, the 1061Aright curved arrow G (Ile405Val) polymorphism of CETP, the Aright curved arrow G (Lys45Glu) polymorphism of MMP3, the -219Gright curved arrow T polymorphism of APOE, the Aright curved arrow G (Ile1205Val) polymorphism of COL3A1, the -863Cright curved arrow A polymorphism of TNF, and the 1454Cright curved arrow G (Leu125Val) polymorphism of PECAM1 in high-risk subjects; and the 1167Cright curved arrow T (Asn389Asn) polymorphism of TGFBR2, the 2386Aright curved arrow G (Ile796Val) polymorphism of SCAP, and the TAAAright curved arrow del polymorphism of PDE4D in low-risk subjects.
|
19424605 |
2009 |
|
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We conducted a case-control study to investigate whether the common variants of genes from the SREBP2 activating-related pathway, involving SREBP2, SCAP, INSIG1 and INSIG2 genes, were associated with coronary heart disease (CHD) of Chinese Han population individually or interactively.
|
19740467 |
2010 |
|
Cytomegalovirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our data demonstrate that the induction of PERK during HCMV infection is necessary for full activation of lipogenesis; this effect appears to be mediated by limiting the levels of Insig1 thus freeing SREBP1-SCAP complexes for SREBP1 processing.
|
23592989 |
2013 |
|
Dental Pulp Necrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Apical papilla represents a source of an enriched mesenchymal stem cell (MSC) population (stem cells of the apical papilla [SCAPs]) that modulates root development and may participate in regenerative endodontic procedures in immature teeth with pulp necrosis.
|
28190588 |
2017 |
|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin.
|
20973890 |
2011 |
|
Dyslipidemias
|
0.010 |
Biomarker
|
group |
BEFREE |
The spontaneous dysmetabolic rhesus monkey model (DysMet RhM) recapitulates this human dyslipidemia and therefore is an attractive preclinical model to evaluate SCAP inhibition as a therapy for this disease population.
|
28521874 |
2017 |
|
Enchondroma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found fewer enchondromas in animals lacking SCAP.
|
31039139 |
2019 |
|
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our study reveals a previously unrecognized negative feedback loop in SCAP/SREBP-1 signaling mediated by miR-29 and suggests that miR-29 treatment may represent an effective means to target GBM.
|
27477273 |
2016 |
|
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Xenograft studies reveal that blocking SCAP N-glycosylation ameliorates EGFRvIII-driven glioblastoma growth.
|
26555173 |
2015 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
Xenograft studies reveal that blocking SCAP N-glycosylation ameliorates EGFRvIII-driven glioblastoma growth.
|
26555173 |
2015 |