|
obsolete Combined hyperlipidemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also report additional common single-nucleotide polymorphisms in the SCAP promoter and coding sequence that were identified by using direct sequencing to screen the genomic DNA of subjects with combined hyperlipidemia.
|
12202990 |
2002 |
|
Liver carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells.
|
14563831 |
2004 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Both SREBP-2 and SCAP are candidates to contribute to the development of atherosclerosis.
|
16466730 |
2006 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Both SREBP-2 and SCAP are candidates to contribute to the development of atherosclerosis.
|
16466730 |
2006 |
|
Hypercholesterolemia
|
0.200 |
Biomarker
|
disease |
RGD |
Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia.
|
16741953 |
2006 |
|
Myocardial Infarction
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
SREBP-2 and SCAP isoforms and risk of early onset myocardial infarction.
|
17383658 |
2008 |
|
Myocardial Infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SREBP-2 and SCAP isoforms and risk of early onset myocardial infarction.
|
17383658 |
2008 |
|
Chronic Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that ten different polymorphisms were associated (P<0.05) with the prevalence of CKD in high- or low-risk subjects: the -519Aright curved arrow G polymorphism of MMP1, the 1061Aright curved arrow G (Ile405Val) polymorphism of CETP, the Aright curved arrow G (Lys45Glu) polymorphism of MMP3, the -219Gright curved arrow T polymorphism of APOE, the Aright curved arrow G (Ile1205Val) polymorphism of COL3A1, the -863Cright curved arrow A polymorphism of TNF, and the 1454Cright curved arrow G (Leu125Val) polymorphism of PECAM1 in high-risk subjects; and the 1167Cright curved arrow T (Asn389Asn) polymorphism of TGFBR2, the 2386Aright curved arrow G (Ile796Val) polymorphism of SCAP, and the TAAAright curved arrow del polymorphism of PDE4D in low-risk subjects.
|
19424605 |
2009 |
|
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We conducted a case-control study to investigate whether the common variants of genes from the SREBP2 activating-related pathway, involving SREBP2, SCAP, INSIG1 and INSIG2 genes, were associated with coronary heart disease (CHD) of Chinese Han population individually or interactively.
|
19740467 |
2010 |
|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin.
|
20973890 |
2011 |
|
Adrenoleukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We used fish which harbor a mutation in the gene encoding the membrane bound transcription factor protease 1 (mbtps1; also called site-1 protease) and embryos in which the Srebp cleavage activating protein (scap) is knocked down to determine the requirement of this pathway in acute ALD.
|
21284674 |
2011 |
|
Cytomegalovirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our data demonstrate that the induction of PERK during HCMV infection is necessary for full activation of lipogenesis; this effect appears to be mediated by limiting the levels of Insig1 thus freeing SREBP1-SCAP complexes for SREBP1 processing.
|
23592989 |
2013 |
|
Intestinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
After 4 days of tamoxifen, Vil-Scap(-) mice succumb with a severe enteropathy and near-complete collapse of intestinal mucosa.
|
25896350 |
2015 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Targeting SCAP N-glycosylation may provide a promising means of treating malignancies and metabolic diseases.
|
26555173 |
2015 |
|
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Xenograft studies reveal that blocking SCAP N-glycosylation ameliorates EGFRvIII-driven glioblastoma growth.
|
26555173 |
2015 |
|
Metabolic Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Targeting SCAP N-glycosylation may provide a promising means of treating malignancies and metabolic diseases.
|
26555173 |
2015 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
Xenograft studies reveal that blocking SCAP N-glycosylation ameliorates EGFRvIII-driven glioblastoma growth.
|
26555173 |
2015 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Xenograft studies reveal that blocking SCAP N-glycosylation ameliorates EGFRvIII-driven glioblastoma growth.
|
26555173 |
2015 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Xenograft studies reveal that blocking SCAP N-glycosylation ameliorates EGFRvIII-driven glioblastoma growth.
|
26555173 |
2015 |
|
Metabolic Syndrome X
|
0.020 |
Biomarker
|
disease |
BEFREE |
We explored the association between the variants of the sterol-regulatory element-binding transcription factor-1 (SREBF1) gene and the SREBP cleavage-activation protein (SCAP) gene with AAP-induced MetS in a genetic case-control study.
|
26982812 |
2016 |
|
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our study reveals a previously unrecognized negative feedback loop in SCAP/SREBP-1 signaling mediated by miR-29 and suggests that miR-29 treatment may represent an effective means to target GBM.
|
27477273 |
2016 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our study reveals a previously unrecognized negative feedback loop in SCAP/SREBP-1 signaling mediated by miR-29 and suggests that miR-29 treatment may represent an effective means to target GBM.
|
27477273 |
2016 |
|
Metabolic Syndrome X
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Effect of an SNP in SCAP gene on lipid-lowering response to rosuvastatin in Indian patients with metabolic syndrome.
|
27885915 |
2016 |
|
Dental Pulp Necrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Apical papilla represents a source of an enriched mesenchymal stem cell (MSC) population (stem cells of the apical papilla [SCAPs]) that modulates root development and may participate in regenerative endodontic procedures in immature teeth with pulp necrosis.
|
28190588 |
2017 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE<sup>-/-</sup> Mice Fed with a High-Fat Diet.
|
28491104 |
2017 |