TPX2, TPX2 microtubule nucleation factor, 22974

N. diseases: 122; N. variants: 2
Disease: Increased drug resistance ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0521857
Disease: Increased drug resistance
Increased drug resistance 		0.010 AlteredExpression phenotype BEFREE The siRNA knockdown of Aurora-A activator TPX2 (targeting protein for Xenopus kinase-like protein 2) increased MK-8745 sensitivity in less-MK-8745-sensitive NHL cell lines, whereas overexpression of TPX2 in high-MK-8745-sensitive NHL cell lines increased drug resistance. 21879811 2012