FOXO1, forkhead box O1, 2308

N. diseases: 380; N. variants: 16
Disease: Septicemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036690
Disease: Septicemia
Septicemia 		0.020 GeneticVariation disease BEFREE For rs2721068 (T/T, T/C-C/C) and rs17446614 (A/A-A/G, G/G), serum levels of foxo1 in sepsis patients were both significantly lower in normal controls. 31492105 2019
CUI: C0036690
Disease: Septicemia
Septicemia 		0.020 Biomarker disease BEFREE TGF-β secreted by MSCs could skew LPS-stimulated macrophage polarization towards the M2-like phenotype, reduce inflammatory reactions, and improve the phagocytic ability via the Akt/FoxO1 pathway, providing potential therapeutic strategies for sepsis. 31771622 2019