FOXO1, forkhead box O1, 2308

N. diseases: 380; N. variants: 16
Disease: Stomach Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE The downregulation of forkhead box O1 (FOXO1) was observed in GC. 31416776 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE Additionally, there was an inverse correlation between FOXO1 and GC stem cell marker LGR5 in human GC specimens. 28970066 2017
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 AlteredExpression disease BEFREE PRMT1 and FOXO1 in GC samples were predominantly expressed in the nucleus. 26472729 2016
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 AlteredExpression disease BEFREE In addition, inactivated FOXO1 expression was associated with SIRT1 expression in human GC tissues and xenograft tumor tissues. 25761483 2016
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE Together, IGF-1/Akt/FoxO1 regulatory machinery appears to be a previously unappreciated signaling axis involved in the carcinogenesis of GC. 25596089 2015
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE Our results indicate that loss of FOXO1 promotes GC growth and metastasis by upregulating HER2 expression and that the HER2 expression is more critical to the induction of GC cell metastasis. 26448177 2015
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE Thus, FOXO1 may be an useful pharmacological indicator to predict CDDP efficacy in gastric cancer treatment. 24202965 2014
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE As their relationship has been inconsistent depending on the cell type, we aimed to investigate whether FOXO1 is associated with NF-κB p65 (RelA) in gastric cancer. 24673584 2014
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE Taken together, our results revealed a novel mechanism of FOXO1 suppression mediated by miR-370 in gastric cancer. 23721824 2013
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE Animal experiments are needed to confirm the anti-angiogenic role of FOXO1 in human gastric cancer. 21696576 2011