|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
More well-designed studies with larger sample size and various ethnic groups and risk factors are needed to establish that KIF1B rs17401966 polymorphism is significantly associated with risk of HCC.
|
30947687 |
2019 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The pooled results indicated that the association between KIF1B (rs17401966) polymorphism and the decreased HCC risk was significant.
|
29881295 |
2018 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have identified common polymorphisms in <i>KIF1B, HLA-DQ, STAT4</i>, and <i>GRIK1</i> with altered risk of HBV-related HCC.
|
30073017 |
2018 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
No significant association was found between the KIF1B variants alone and the risk of HCC.
|
27122668 |
2016 |
|
Liver carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of KIF1B in HCC tissues is associated with poor prognosis; additional clinical studies are needed to confirm whether KIF1B can serve as a prognostic marker.
|
26217094 |
2015 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the subgroup analysis by gender, KIF1B rs17401966 polymorphism was significantly associated with HCC risk in man (OR = 0.57, 95 % CI 0.51-0.64, P < 0.001).
|
24952890 |
2014 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A genetic variant at KIF1B predicts clinical outcome of HBV-related hepatocellular carcinoma in Chinese.
|
25153661 |
2014 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Overall, the G allele at rs17401966 of the KIF1B gene was associated with a significantly decreased risk for HCC (OR = 0.81, 95%CI: 0.70-0.93; P = 0.003).
|
23634229 |
2013 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the KIF1B gene SNP (rs174019660) investigated in this study showed no significant association with HBV-related HCC in Thai patients infected with HBV, indicating that there must be other mechanisms or pathways involved in the development of HCC.
|
23803045 |
2013 |
|
Liver carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
This study showed the new locus identified for HCC, KIF1B, was not associated with progression to CHB, implying distinct genetic susceptibility factor contributes to the progression from hepatitis B virus infection to HCC.
|
22363396 |
2012 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
|
22807686 |
2012 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC.
|
22712471 |
2012 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A recent genome wide association study (GWAS) study conducted on a Chinese population has reported the involvement of a KIF1B genetic variant in Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
|
23028799 |
2012 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers.
|
20676096 |
2010 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers.
|
20676096 |
2010 |
|
Liver carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios.
|
20676096 |
2010 |