|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Some of the compounds were found to possess excellent dual activity, hence they may be promising candidates to modify and evaluate their dual action, i.e., insulin release to combat diabetes and ALR2 inhibition to prevent/treat diabetic complications.
|
30818176 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aldose reductase (AR) is involved in the pathogenesis of diabetes, which is one of the major threats to global public health.
|
29792152 |
2019 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression and activity of PKC and the protein levels of related signaling molecules with the AR inhibitor sorbinil showed that AR enzyme may have a key role in the expression of PKC enzyme and oxidative stress during diabetes.
|
31743046 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In our animal study, increased numbers of RMG observed in streptozotocin (STZ)-induced diabetic retina was substantially lower when diabetes was induced in AR knockout mice.
|
30682331 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia.
|
30077669 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mice have low levels of AR, thus raising them to human levels would be a more clinically relevant model to study changes in diabetes under atherosclerosis regression conditions.
|
29891593 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several of these activities, together with the effect of ellagic acid on insulin, glycogen, phosphatases, aldose reductase, sorbitol accumulation, advanced glycation end-product formation, and resistin secretion, may explain its effects on metabolic syndrome and diabetes.
|
29847844 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Indeed, AKR1B1 overexpression is related to diabetes secondary complications and, in some cases, with cancer.
|
29705708 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aldose reductase (ALR), the first and rate-limiting enzyme involved in polyol pathway plays a central role in diabetes and its related complications, including diabetic retinopathy (DR).
|
27835059 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased glucose flux into the aldose reductase (AR) pathway during diabetes was reported to exert deleterious effects on the kidney.
|
28386557 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aldo-keto reductases (including AKR1B1 and AKR1B10) constitute a family of oxidoreductases that have been implicated in the pathophysiology of diabetes and cancer, including colorectal cancer (CRC).
|
28929377 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent efforts to develop cure for chronic diabetic complications have led to the discovery of potent inhibitors against aldose reductase (AKR1B1, EC 1.1.1.21) whose role in diabetes is well-evident.
|
28917123 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
According to previous research, aldose reductase (AR) plays a vital role in the oxidative stress-related complications of diabetes.
|
28057038 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several Chinese herbs, indeed, elicit potent anti-inflammatory, antioxidant, anti-angiogenic, anti-apoptotic, peroxisome proliferator-activated receptor-gamma receptor agonistic, platelet-activating factor antagonistic, aldose reductase inhibitory and various other beneficial pharmacological activities, required to counteract the pathological conditions prevalent in retina during diabetes.
|
28124440 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aldose reductase (AR; gene AKR1B1) is the rate-limiting enzyme of the polyol pathway and has been associated with diabetes and atherosclerosis.
|
26873505 |
2016 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
AR-TG mice homozygous for the transgene demonstrated a conditional cataract phenotype, whereby they developed lens vacuoles and cataract-associated structural changes only after induction of experimental diabetes; no such changes were observed in AR-TG heterozygotes or nontransgenic mice with or without experimental diabetes induction.
|
25541468 |
2015 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and AKR1B1) or retinopathy (VEGF, AKR1B1, and EPO), and only a few studies were carried out for genetic susceptibility to cardiovascular diseases (ADIPOQ, GLUL) in patients with diabetes.
|
25169573 |
2014 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The commonly reported association of AKR1B1 with DR may be due to an association of the gene with younger age at onset of diabetes.
|
20424224 |
2010 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis.
|
18451330 |
2008 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aldose reductase appears to be involved in a variety of disease states other than diabetes, presumably due to its ability to catalyze the reduction of a broad spectrum of aldehydes, including some cytotoxic products of lipid peroxidation.
|
15736047 |
2005 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The C-106T polymorphism was genotyped in 228 cases (microalbuminuria or overt proteinuria) and 220 controls (normoalbuminuria with diabetes duration > or =10 years) for a case-control comparison, and the association with erythrocyte AR content was investigated.
|
14582038 |
2003 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies have shown that polymorphisms located at positions -106 and approximately -2100 base pairs (5'ALR2) in the regulatory region of the aldose reductase gene are associated with susceptibility to microvascular complications in patients with diabetes.
|
12943962 |
2003 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prevention of diabetes-induced albuminuria in transgenic rats overexpressing human aldose reductase.
|
12166624 |
2002 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous work has implicated aldose reductase in a pathway whereby aldose reductase-induced use of nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH) drives the pentose phosphate pathway, which culminates in a protein kinase C-induced increase in glomerular prostaglandin production and loss of mesangial cell contractility as a possible cause of hyperfiltration and glomerular dysfunction in diabetes.
|
10997684 |
2000 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was a highly significant increase in the frequency of the Z-2 5'ALR2 allele and Z-2/X (where X is not Z+2) genotype in patients with diabetic retinopathy (n = 159) compared with those without who had diabetes of 20 years' duration (uncomplicated, n = 70; chi(2) = 17.0, P < 0.0001).
|
11095596 |
2000 |