|
Retinal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review we examine possible mechanisms that relate AR to molecular signaling cascades and thus explain why AR inhibition is an effective strategy against colon cancer as well as diseases of the eye such as uveitis, cataract, and retinopathy.
|
30362099 |
2019 |
|
Retinal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Some of these compounds had a potent inhibitory activity for human recombinant aldose reductase (ALR2), an enzyme which converts glucose into sorbitol and plays a key role in development of complications arising from diabetes, such as retinopathy, nephropathy, neuropathy and cataract formation.
|
30818176 |
2019 |
|
Retinal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Protein kinase C (PKC) and aldose reductase (AR) enzyme activities are increased in diabetes and its complications such as retinopathy, nephropathy and neuropathy.
|
31743046 |
2019 |
|
Retinal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Literature suggests ALR2 inhibitors such as epalrestat to possess significant potential in retinopathy and neuropathy.
|
30030901 |
2018 |
|
Retinal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings suggest a statistically significant association of AKR1B1 -106C>T polymorphism with retinopathy in North Indian patients.
|
27640118 |
2016 |
|
Retinal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Aldose reductase (AR) is thought to play a role in the pathogenesis of diabetic eye diseases, including cataract and retinopathy.
|
25541468 |
2015 |
|
Retinal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and AKR1B1) or retinopathy (VEGF, AKR1B1, and EPO), and only a few studies were carried out for genetic susceptibility to cardiovascular diseases (ADIPOQ, GLUL) in patients with diabetes.
|
25169573 |
2014 |
|
Retinal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results indicate that inhibition of AR in HREC prevents tube formation by inhibiting the VEGF-induced activation of the Akt and p38-MAPK pathway and suggest a mediatory role of AR in ocular neovascularization generally implicated in retinopathy and AMD.
|
22658411 |
2013 |
|
Retinal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To study the C(-106)T polymorphism in the promoter of the aldose reductase (ALR2) gene: (a) its local prevalence and (b) its modulation of the susceptibility for developing retinopathy.
|
16701918 |
2006 |
|
Retinal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Phenotypic heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes.
|
12882871 |
2003 |
|
Retinal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in (CA)( n) present upstream of the promoter of the aldose reductase (ALR2 ) gene have been shown to be associated with retinopathy in different ethnic populations.
|
12660865 |
2003 |
|
Retinal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The objective of this study was to investigate cross-sectionally and longitudinally whether polymorphism of the (A-C)n dinucleotide repeat sequence of the aldose reductase (AR) gene may modulate risk for diabetic nephropathy or retinopathy in Japanese patients with type 1 diabetes.
|
12542725 |
2003 |
|
Retinal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim of this study therefore, was to investigate the relationship between the aldose reductase gene and type 2 diabetic microvascular complications such as diabetic nephropathy and retinopathy.
|
11796181 |
2002 |
|
Retinal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Association of retinopathy with a microsatellite at 5' end of the aldose reductase gene in Chinese patients with late-onset Type 2 diabetes.
|
11449315 |
2001 |
|
Retinal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
There is evidence that the development of retinopathy in type 2 diabetes is associated with a microsatellite polymorphism at 5' of the aldose reductase gene.
|
11359468 |
2001 |
|
Retinal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The C/Z-2 C(-106)T/5' ALR2 haplotype was found in 33.3% of the patients with retinopathy and 8.7% of the patients with uncomplicated diabetes.
|
11095596 |
2000 |
|
Retinal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
By means of a longitudinal-retrospective study, we aimed to seek for a relationship between the rate of progression of retinopathy and the (AC)23 allele of the VNTR associated to the ALR2 gene.
|
10741565 |
2000 |
|
Retinal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The Z-2 allele frequency was significantly higher in subjects with diabetic retinopathy than those without retinopathy (0.35 vs. 0.20, P=0.039), suggesting that aldose reductase is involved in the development of diabetic retinopathy.
|
10510950 |
1999 |
|
Retinal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
1 kb upstream of the AR2 gene may enhance gene transcription and may be a genetic risk factor, which determines the predisposition to retinopathy in Japanese patients with NIDDM.
|
10579460 |
1999 |
|
Retinal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A significant decrease in the frequency of the 8.2 kilobase (kb) Bam-HI ALR2 genotype and 8.2 kb allele was found in patients with nephropathy (nephropaths) compared to those with retinopathy alone (retinopaths) (p < 0.05 and 0.25, respectively).
|
8777332 |
1996 |
|
Retinal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
One of the alleles (Z-2) was found to be associated with early onset of retinopathy in patients with non-insulin-dependent diabetes (P = 0.007), suggesting that aldose reductase or a gene in the close vicinity may be involved in the pathogenesis of this diabetic complication.
|
7789640 |
1995 |