|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mite sensitizations and FLG variants had a synergistic effect on the development of asthma.
|
25528737 |
2015 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Filaggrin null mutations associate with atopic eczema and also with asthma when present with eczema.
|
20500796 |
2010 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
FLG mutations are also significantly associated with asthma (OR, 1.48; 95% CI, 1.32-1.66).
|
19501237 |
2009 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Children with filaggrin variants had a marked and persistent increase in acute severe asthma exacerbations from 1 yr of age (incidence ratio 2.40 [1.19-4.81], p = 0.01) and increased risk of asthma by age 5 (odds ratio 2.62 [1.12-6.11], p = 0.03).
|
20573035 |
2010 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Children with nonallergic rhinitis also had increased asthma prevalence (20% vs 5%; P = .001) but showed no association with filaggrin null-mutations, eczema, food sensitization, total IgE, blood eosinophil count, FeNO, or bronchial responsiveness.
|
20816191 |
2010 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Mutations in the filaggrin gene (FLG) confer major susceptibility to eczema and related asthma.
|
18325573 |
2008 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Additional insights from rare monogenic disorders that can present as severe asthma include recognition that loss-of-function variants in the filaggrin gene known to cause ichthyosis vulgaris are consistently associated with more severe asthma outcomes.
|
30896504 |
2019 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The replication and its statistical significance underlines the importance of the FLG polymorphisms and the importance of the skin barrier function in the development of AD and subsequent asthma.
|
19538357 |
2009 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Filaggrin (FLG) loss-of-function variants (null-alleles) are associated with eczema and asthma in association with eczema.
|
19408338 |
2009 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have recently shown that null mutations in the filaggrin gene (FLG) are an important predisposing factor for childhood eczema and eczema-associated asthma, but persistence to adulthood has not been analyzed.
|
16990802 |
2007 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These SNPs (rs11204971, rs3126085, rs7936562, rs712484 and rs6010620) at AD susceptibility genes/loci FLG, 11q13.5 and 20q13.33 were not associated with asthma in this study.
|
22545103 |
2012 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study was designed to examine the association between loss-of-function mutations in the filaggrin gene (FLG) and atopic dermatitis (AD) and asthma in adult twins.
|
27653621 |
2016 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To determine whether FLG mutations are associated with increased prescribing for eczema and asthma and whether increased prescribing is associated with increased healthcare costs.
|
29851030 |
2018 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have hypothesized that skin barrier defects caused by FLG mutations allows allergens to penetrate the epidermis and to interact with antigen-presenting cells, leading to the development of atopic disorders including asthma.
|
21173567 |
2011 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In fact, the exposure to environmental factors during early childhood may induce a long-lasting altered genetic state adapting to a persistent "Th2 state" thus influencing the development of asthma or atopic dermatitis and food allergy if alterations involve the filaggrin gene.
|
23809342 |
2013 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Early food sensitization and the presence of an FLG mutation in infants with early eczema increase the risk for later asthma, but the combination of the 2 factors does not represent a clinically useful approach to reliably identify children at risk.
|
22030464 |
2011 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recent reports indicated that nonsense mutations in filaggrin (FLG) found in ichthyosis vulgaris (IV) patients are predisposing factors for atopic dermatitis (AD) with asthma.
|
18420385 |
2008 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.
|
30552067 |
2019 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
AD, early-onset AD, palmar hyperlinearity, and asthma showed significant associations with the combined FLG null genotype.
|
27840886 |
2017 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the delayed-effects models, 'FLG variants plus allergic sensitization' and 'FLG variants plus eczema' increased the risk of subsequent asthma by 4.93-fold (95% CI 3.61-6.71) and 3.33-fold (95% CI 2.45-4.51), respectively, during the first 18 years of life.
|
25277085 |
2014 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Additional insights from rare monogenic disorders that can present as severe asthma include recognition that loss-of-function variants in the filaggrin gene known to cause ichthyosis vulgaris are consistently associated with more severe asthma outcomes.
|
31090575 |
2019 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Filaggrin mutations, atopic eczema, hay fever, and asthma in children.
|
18396323 |
2008 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We then tested the impact of the choice of the most common definitions of 'cases' and 'controls' on AD prevalence estimates and associated risk factors (including filaggrin mutations) among children aged 5 years in two population-based birth cohorts: the Manchester Asthma and Allergy Study (MAAS) and Asthma in Ashford.
|
30822368 |
2019 |
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, little is known about the contribution of loss-of-function mutations in the gene encoding filaggrin (FLG) gene, which are considered to be predisposing factors for eczema and asthma, to these associations.
|
30195067 |
2018 |