Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The identification of mutations in the barrier protein filaggrin as conferring major susceptibility to atopic dermatitis and atopic dermatitis related asthma has reconfigured our understanding of disease mechanisms and highlights the importance of epidermal barrier disruption as a primary event in the disease.
|
18769192 |
2008 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mite sensitizations and FLG variants had a synergistic effect on the development of asthma.
|
25528737 |
2015 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Filaggrin null mutations associate with atopic eczema and also with asthma when present with eczema.
|
20500796 |
2010 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
FLG mutations are also significantly associated with asthma (OR, 1.48; 95% CI, 1.32-1.66).
|
19501237 |
2009 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Children with filaggrin variants had a marked and persistent increase in acute severe asthma exacerbations from 1 yr of age (incidence ratio 2.40 [1.19-4.81], p = 0.01) and increased risk of asthma by age 5 (odds ratio 2.62 [1.12-6.11], p = 0.03).
|
20573035 |
2010 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Children with nonallergic rhinitis also had increased asthma prevalence (20% vs 5%; P = .001) but showed no association with filaggrin null-mutations, eczema, food sensitization, total IgE, blood eosinophil count, FeNO, or bronchial responsiveness.
|
20816191 |
2010 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Mutations in the filaggrin gene (FLG) confer major susceptibility to eczema and related asthma.
|
18325573 |
2008 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Additional insights from rare monogenic disorders that can present as severe asthma include recognition that loss-of-function variants in the filaggrin gene known to cause ichthyosis vulgaris are consistently associated with more severe asthma outcomes.
|
30896504 |
2019 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The replication and its statistical significance underlines the importance of the FLG polymorphisms and the importance of the skin barrier function in the development of AD and subsequent asthma.
|
19538357 |
2009 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Filaggrin (FLG) loss-of-function variants (null-alleles) are associated with eczema and asthma in association with eczema.
|
19408338 |
2009 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have recently shown that null mutations in the filaggrin gene (FLG) are an important predisposing factor for childhood eczema and eczema-associated asthma, but persistence to adulthood has not been analyzed.
|
16990802 |
2007 |
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results underline the role of the epidermal barrier and filaggrin insufficiency in the pathogenesis of atopic eczema and eczema-associated asthma.
|
29068602 |
2017 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These SNPs (rs11204971, rs3126085, rs7936562, rs712484 and rs6010620) at AD susceptibility genes/loci FLG, 11q13.5 and 20q13.33 were not associated with asthma in this study.
|
22545103 |
2012 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study was designed to examine the association between loss-of-function mutations in the filaggrin gene (FLG) and atopic dermatitis (AD) and asthma in adult twins.
|
27653621 |
2016 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To determine whether FLG mutations are associated with increased prescribing for eczema and asthma and whether increased prescribing is associated with increased healthcare costs.
|
29851030 |
2018 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have hypothesized that skin barrier defects caused by FLG mutations allows allergens to penetrate the epidermis and to interact with antigen-presenting cells, leading to the development of atopic disorders including asthma.
|
21173567 |
2011 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In fact, the exposure to environmental factors during early childhood may induce a long-lasting altered genetic state adapting to a persistent "Th2 state" thus influencing the development of asthma or atopic dermatitis and food allergy if alterations involve the filaggrin gene.
|
23809342 |
2013 |
Asthma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Three study populations were included: (i) a random sample of 3335 subjects aged 18-69 years from the general population in Copenhagen who underwent general health examination; (ii) a total of 499 patients seen in our dermatitis clinic since 2009 and who were filaggrin genotyped as a part of the routine diagnostic work up; and (iii) a prospective, longitudinal, birth cohort study of 411 children born to mothers with a history of asthma.
|
21501248 |
2012 |
Asthma
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Early food sensitization and the presence of an FLG mutation in infants with early eczema increase the risk for later asthma, but the combination of the 2 factors does not represent a clinically useful approach to reliably identify children at risk.
|
22030464 |
2011 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recent reports indicated that nonsense mutations in filaggrin (FLG) found in ichthyosis vulgaris (IV) patients are predisposing factors for atopic dermatitis (AD) with asthma.
|
18420385 |
2008 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.
|
30552067 |
2019 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
AD, early-onset AD, palmar hyperlinearity, and asthma showed significant associations with the combined FLG null genotype.
|
27840886 |
2017 |
Asthma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the delayed-effects models, 'FLG variants plus allergic sensitization' and 'FLG variants plus eczema' increased the risk of subsequent asthma by 4.93-fold (95% CI 3.61-6.71) and 3.33-fold (95% CI 2.45-4.51), respectively, during the first 18 years of life.
|
25277085 |
2014 |