KDM6B, lysine demethylase 6B, 23135

N. diseases: 173; N. variants: 5
Disease: Arteriosclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.020 Biomarker disease BEFREE Bone marrow of myeloid Kdm6b deficient (Kdm6b<sup>del</sup>) mice or wild type littermates (Kdm6b<sup>wt</sup>) was transplanted to lethally irradiated Ldlr<sup>-/-</sup> mice fed a high fat diet for 9 weeks to induce atherosclerosis. 29908485 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.020 Biomarker disease BEFREE Our findings unveil epigenetic regulations of LPS upon NF-κB pathway and identify Jmjd3 as a critical modulator of NF-κB pathway and potential therapeutic target for NF-κB related diseases including atherosclerosis. 28189690 2017