Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the histopathological presence of Homer-Wright rosettes and immunohistochemical markers such as CD99, FLI-1 and CK are valuable factors for the diagnosis of ES, although cytogenetic analysis is considered the gold standard.
|
31788090 |
2019 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma.
|
29358035 |
2018 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma.
|
29091716 |
2017 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma.
|
28720588 |
2017 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS/FLI regulates myriad genes required for Ewing sarcoma development.
|
28847958 |
2017 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, to induce transformation, EWS-FLI requires the presence of additional molecular events, including the expression of CD99, a cell surface molecule with critical relevance for the pathogenesis of EWS.
|
27792997 |
2016 |
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of Fli-1 also underlies a number of virally induced leukemias, including Friend virus-induced erythroleukemia and various types of human cancers, and it is the target of chromosomal translocations in childhood Ewing's sarcoma.
|
24909161 |
2015 |
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we report a case of malignant neuroectodermal gastrointestinal tumor which immunophenotypically unusually expressed FLI-1, occurring in a 29-year-old man with a previous medical history of Ewing sarcoma.
|
26163185 |
2015 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We therefore evaluated the translational potential of potent and specific LSD1 inhibition with HCI2509 on the transcriptional program of both EWS/FLI and EWS/ERG as well as the downstream oncogenic phenotypes driven by EWS/ETS fusions in both in vitro and in vivo models of Ewing sarcoma.
|
24963049 |
2014 |
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, we noted that JGCTs can show immunohistochemical expression of Fli-1, a transcription factor expressed by Ewing sarcoma, a neoplasm that is occasionally in the differential diagnosis of JGCT.
|
24300529 |
2014 |
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Stable suppression of RUNX3 expression in the Ewing sarcoma cell line A673 delayed colony growth in anchorage independent soft agar assays and reversed expression of EWS/FLI-responsive genes.
|
24812032 |
2014 |
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that GGAA-microsatellite polymorphisms observed in human populations modulate EWS/FLI-mediated gene expression and may influence disease susceptibility in Ewing sarcoma.
|
25093581 |
2014 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data reveal previously unknown molecular functions for a cytoplasmic intermediate filament protein, KRT17, in coordinating EWS/FLI- and GLI1-mediated oncogenic transformation and cellular adhesion in Ewing sarcoma.
|
24043308 |
2013 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data define a new pathway downstream of EWS/FLI required for oncogenic maintenance in Ewing sarcoma.
|
23527175 |
2013 |
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these data reveal a previously unknown molecular function for EWS/FLI, demonstrate a more highly coordinated oncogenic transcriptional hierarchy mediated by EWS/FLI than previously suspected, and implicate a new paradigm for therapeutic intervention aimed at controlling NuRD activity in Ewing sarcoma tumors.
|
23178492 |
2013 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since GGAA-containing microsatellites within key target genes are necessary for Ewing sarcoma-specific EWS/FLI DNA binding and gene activation, and gene expression is positively correlated with the number of repeat motifs in the promoter/enhancer region, we sought to determine if significant polymorphisms exist between African and European populations which might contribute to observed differences in Ewing sarcoma incidence and outcomes.
|
22749036 |
2012 |
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ewing sarcoma family tumors (ESFT) are highly aggressive and highly metastatic tumors caused by a chromosomal fusion between the Ewing sarcoma protein (EWS) with the transcription factor FLI-1.
|
22241085 |
2012 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD99 and FLI-1 are the currently accepted immunohistochemical markers for Ewing sarcoma, but their accuracy has been controversial.
|
22446943 |
2012 |
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One such chimera is EWS-FLI, the most frequently occurring translocation in Ewing Sarcoma, a malignant bone and soft tissue tumor of children and young adults.
|
22086061 |
2012 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
FLI-1 has been described to be a useful marker for Ewing sarcoma, particularly when hematolymphoid markers are negative.
|
21084965 |
2011 |
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition to EWS/FLI, variant translocation fusions belonging to the TET/ETS family have been identified in Ewing's sarcoma.
|
21872822 |
2011 |
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For example, nearly all cases of Ewing's sarcoma contain the (11;22)(q24;q12) chromosomal translocation that encodes the EWS/FLI oncoprotein.
|
20543858 |
2010 |
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Fli-1 aberrant regulation is also observed in human malignancies, including Ewing's sarcoma, which is often linked to expression of the EWS/Fli-1 fusion oncoprotein.
|
19282832 |
2009 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we combined transcriptional analysis, whole genome localization data, and RNA interference knockdown to identify glutathione S-transferase M4 (GSTM4) as a critical EWS/FLI target gene in Ewing's sarcoma.
|
19718047 |
2009 |
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS/FLI functions as an aberrant transcription factor to regulate genes that mediate the oncogenic phenotype of Ewing's sarcoma.
|
19920188 |
2009 |