|
Smith-Magenis syndrome
|
0.300 |
GeneticVariation
|
disease |
ORPHANET |
We present two patients with SMS who have interstitial deletions at 17p11.2 but are not deleted for currently available commercial FISH probes that include FLII; both patients have deletions that are demonstrated with probes containing the RAI1 gene.
|
15690371 |
2005 |
|
Smith-Magenis syndrome
|
0.300 |
GeneticVariation
|
disease |
ORPHANET |
The homologous human FLII gene encodes a 1269-residue protein with 58% amino acid sequence identity and is deleted in Smith-Magenis syndrome.
|
9177775 |
1997 |
|
Smith-Magenis syndrome
|
0.300 |
GeneticVariation
|
disease |
ORPHANET |
The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2.
|
7825574 |
1995 |
|
Friend leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Friend leukemia integration 1 (Fli-1) is a member of the E26 transformation-specific (ETS) transcription factor family.
|
31626853 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The xenograft experiment indicated that intraperitoneal injection of FLI-06 inhibited tumor growth and increased cell apoptosis.
|
31571917 |
2019 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the histopathological presence of Homer-Wright rosettes and immunohistochemical markers such as CD99, FLI-1 and CK are valuable factors for the diagnosis of ES, although cytogenetic analysis is considered the gold standard.
|
31788090 |
2019 |
|
Friend leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, silencing of CD226 in megakaryocytic cells down-regulated the expression of early stage transcription factors includes GATA-binding factor 1 (GATA-1) and friend leukemia integration 1 (FLI-1), but not late-stage nuclear factor, erythroid 2 (NF-E2).
|
30738249 |
2019 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that C10 regulated the expression of Bax, c-Myc, Bcl-2, P38/AMPK and ERK 1/2, activated the expression of Caspase-3, -8, and PARP at the protein level in the apoptosis pathway of the two leukemia cell types, and inhibited the expression of erythroleukemia carcinogene Fli-1 in the human erythroleukemia cell line HEL.
|
29990873 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma.
|
29358035 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the present study, Fli‑1 was highly expressed in HCC samples and tumor cell lines. knockdown of Fli‑1 with small interfering (si)RNAs significantly reduced the colony formation and metastasis capacity of HCC cell lines in vitro.
|
29138848 |
2018 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma.
|
29358035 |
2018 |
|
Adult Erythroleukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that C10 regulated the expression of Bax, c-Myc, Bcl-2, P38/AMPK and ERK 1/2, activated the expression of Caspase-3, -8, and PARP at the protein level in the apoptosis pathway of the two leukemia cell types, and inhibited the expression of erythroleukemia carcinogene Fli-1 in the human erythroleukemia cell line HEL.
|
29990873 |
2018 |
|
Erythroleukemia (Erythroid/Myeloid)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that C10 regulated the expression of Bax, c-Myc, Bcl-2, P38/AMPK and ERK 1/2, activated the expression of Caspase-3, -8, and PARP at the protein level in the apoptosis pathway of the two leukemia cell types, and inhibited the expression of erythroleukemia carcinogene Fli-1 in the human erythroleukemia cell line HEL.
|
29990873 |
2018 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, expression of Spi‑1/PU.1 in a Fli‑1 producing erythroleukemia cell line in which fli‑1 is activated, resulted in increased proliferation through activation of growth promoting proteins MAPK, AKT, cMYC and JAK2.
|
28586009 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Because of the small round blue cell morphology and negative immunohistochemical staining for pan-melanocytic cocktail (HMB45, anti MART1 and anti-tyrosinase) and SOX10 in both cases, FLI-1 immunostaining was requested as part of the tumors workup.
|
28605142 |
2017 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma.
|
29091716 |
2017 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma.
|
28720588 |
2017 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS/FLI regulates myriad genes required for Ewing sarcoma development.
|
28847958 |
2017 |
|
Friend leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Friend leukemia integration site 1 (FLI-1) nuclear transcription factor has been proposed as a suitable tool in the differential diagnosis of small round cell sarcomas.
|
28605142 |
2017 |
|
Friend leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The hematopoietic TFs implicated in patients with impaired platelet function and number include runt-related transcription factor 1, Fli-1 proto-oncogene, E-twenty-six (ETS) transcription factor (friend leukemia integration 1), GATA-binding protein 1, growth factor independent 1B transcriptional repressor, ETS variant 6, ecotropic viral integration site 1, and homeobox A11.
|
28416505 |
2017 |
|
Adult Erythroleukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, expression of Spi‑1/PU.1 in a Fli‑1 producing erythroleukemia cell line in which fli‑1 is activated, resulted in increased proliferation through activation of growth promoting proteins MAPK, AKT, cMYC and JAK2.
|
28586009 |
2017 |
|
Erythroleukemia (Erythroid/Myeloid)
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, expression of Spi‑1/PU.1 in a Fli‑1 producing erythroleukemia cell line in which fli‑1 is activated, resulted in increased proliferation through activation of growth promoting proteins MAPK, AKT, cMYC and JAK2.
|
28586009 |
2017 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, to induce transformation, EWS-FLI requires the presence of additional molecular events, including the expression of CD99, a cell surface molecule with critical relevance for the pathogenesis of EWS.
|
27792997 |
2016 |
|
Friend leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The friend leukemia insertion site 1 (Fli-1) belongs to the Ets family of transcription factors.
|
26424096 |
2016 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of Fli-1 also underlies a number of virally induced leukemias, including Friend virus-induced erythroleukemia and various types of human cancers, and it is the target of chromosomal translocations in childhood Ewing's sarcoma.
|
24909161 |
2015 |