|
Round cell sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ewing sarcoma is the prototype of round cell sarcoma whereas in CIC sarcomas, focal pleomorphism and epithelioid morphology can predominate.
|
31802230 |
2020 |
|
Round cell sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
FISH analysis showed significant CIC rearrangement enabling a final diagnosis of an undifferentiated small round cell sarcoma harboring the t(4;19)(q35;q13.1) and CIC-DUX4 fusion.
|
30989672 |
2019 |
|
Round cell sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differential diagnoses such as rhabdomyosarcoma, desmoplastic small round blue cell tumor, hematolymphoid neoplasm, neuroblastoma, and CIC-DUX round cell sarcoma were ruled out based on immunohistochemistry, genetic studies, and histology.
|
30067549 |
2018 |
|
Round cell sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma.
|
28188754 |
2017 |
|
Round cell sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Primary CIC-DUX4 round cell sarcoma of the kidney: A treatment-refractory tumor with poor outcome.
|
27919577 |
2017 |
|
Round cell sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CIC is also involved in chromosomal translocation-associated gene fusions in highly aggressive small round cell sarcoma that is biologically and clinically distinct from Ewing sarcoma.
|
28985030 |
2017 |
|
Round cell sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
No Ewing sarcoma or other sarcoma tested showed coexpression of these transcripts, while one ETV1/ETV4/ETV5 triple positive previously unclassified round cell sarcoma was identified as harbouring a CIC rearrangement by break-apart fluorescence in-situ hybridization (FISH).
|
27790742 |
2017 |
|
Round cell sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, we made a final pathological diagnosis of t(10;19) CIC-DUX4-positive undifferentiated small round cell sarcoma.
|
28645808 |
2017 |
|
Round cell sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Round cell sarcoma with CIC-DUX4 gene fusion: Discussion of the distinctive cytomorphologic, immunohistochemical, and molecular features in the differential diagnosis of round cell tumors.
|
26800124 |
2016 |
|
Round cell sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among these is a rare round-cell sarcoma that harbors a CIC gene rearrangement known as CIC-rearranged undifferentiated round-cell sarcoma, which is most commonly fused to the DUX4 gene.
|
27562494 |
2016 |
|
Round cell sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A case report of CIC-rearranged undifferentiated small round cell sarcoma in the cerebrum.
|
27324529 |
2016 |
|
Round cell sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We evaluated BRG1 and INI1 expression in 12 SCCOHTs and in a series of 122 tumors that could mimic SCCOHT morphologically: 9 juvenile granulosa cell tumors, 47 adult granulosa cell tumors, 33 high-grade ovarian serous carcinomas, 9 desmoplastic round cell tumors, 13 Ewing sarcomas (5 from the pelvis and 8 from soft tissues), 1 round cell sarcoma associated with CIC-DUX4 translocation from soft tissue (thigh), 1 case of high-grade endometrial stromal sarcoma of the ovary, and 9 melanomas.
|
26135561 |
2015 |
|
Round cell sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma.
|
25007147 |
2014 |
|
Round cell sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: a novel highly aggressive soft tissue tumor with distinctive histopathology.
|
23887164 |
2013 |
|
Round cell sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although additional cases with more extensive follow-up studies are needed, we believe that EWSR1-negative undifferentiated small round cell sarcoma with CIC/DUX4 gene fusion should be added to the list of new sarcoma variants with the possibility of lymph node metastasis.
|
24213312 |
2013 |