Well Differentiated Oligodendroglioma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
CIC is a transcription factor that is mutated in most patients with oligodendrogliomas; these mutations are believed to be a key oncogenic event in such cancers.
|
29844126 |
2018 |
Well Differentiated Oligodendroglioma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
CIC loss-of-function mutations are frequently observed in several human neoplasms such as oligodendroglioma, and lung and gastric carcinoma.
|
28985030 |
2017 |
Well Differentiated Oligodendroglioma
|
0.200 |
Biomarker
|
disease |
BEFREE |
More recently described biomarkers, including the non-balanced translocation leading to 1p/19q codeletion, promoter hypermethylation of the MGMT gene, mutations of the IDH1 or IDH2 gene, and mutations of FUBP1 (on 1p) or CIC (on 19q), have greatly enhanced our understanding of oligodendroglioma biology, although their diagnostic, prognostic, and predictive roles are less clear.
|
25943885 |
2015 |
Well Differentiated Oligodendroglioma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Higher expression of the oncogenic ETV transcription factors in the CIC-mutant oligodendrogliomas may make these tumors more aggressive than the CIC-wild type tumors.
|
26357005 |
2015 |
Well Differentiated Oligodendroglioma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Causal genetic changes in oligodendrogliomas (OD) with 1p/19q co-deletion include mutations in IDH1, IDH2, CIC, FUBP1, TERT promoter and NOTCH1.
|
25694352 |
2015 |
Well Differentiated Oligodendroglioma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All xenograft-producing gliomas harbored "lineage-defining" mutations in CIC (oligodendroglioma) or TP53 (astrocytoma), and 6 of 8 additionally had activating mutations in PIK3CA or amplification of PDGFRA, MET, or N-MYC.
|
24714777 |
2014 |
Well Differentiated Oligodendroglioma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ACLY or phospho-ACLY were similarly reduced in CIC-mutant 1p19q co-deleted oligodendroglioma patient samples.
|
25277207 |
2014 |
Well Differentiated Oligodendroglioma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In contrast to oligodendrogliomas where CIC mutations were always detected along with 1p/19q co-deletion, CIC mutations were only found in 52 % of the 1p/19q co-deleted oligoastrocytomas.
|
22588899 |
2012 |
Well Differentiated Oligodendroglioma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Of the 21 non-synonymous somatic mutations in 20 CIC-mutant oligodendrogliomas, nine were in exon 5 within an annotated DNA-interacting domain and three were in exon 20 within an annotated protein-interacting domain.
|
22072542 |
2012 |
Well Differentiated Oligodendroglioma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
CIC and FUBP1 mutations occurred frequently in oligodendrogliomas (46% and 24%, respectively) but rarely in astrocytomas or oligoastrocytomas ( more than 10%).
|
22869205 |
2012 |
Well Differentiated Oligodendroglioma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins.
|
21817013 |
2011 |
Well Differentiated Oligodendroglioma
|
0.200 |
GeneticVariation
|
disease |
CLINVAR |
|
|
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