|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models.
|
12609962 |
2003 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although innumerable reports have been published in which P-gp has been shown to confer MDR to malignant (including leukemia) cells, so far, large-scale studies in the clinical setting have not convincingly proven that MDR1 plays a major role in clinical drug resistance when the influence of other known prognostic factors in human leukemia are taken into account.
|
11185984 |
2000 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bortezomib is a promising potential therapy for acute leukemia, especially mdr1 drug-resistant leukemia.
|
22145750 |
2012 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Calculating the mean values we found: (i) a distinctly lower mdr1 gene expression in primary ALL and first relapses compared to bone marrow from healthy donors, (ii) no change in mdr1 and mrp, but a decreased topoisomerase II alpha gene expression in first relapses of ALL compared to the primary leukaemia, and (iii) increased mdr1 and mrp levels combined to decreased topoisomerase II alpha levels in recurrent relapses of ALL showing significant correlations (mdr1/mrp: rs = +0.6833, P < 0.05; mdr1/topoII alpha: rs = -0.6727, P < 0.05).
|
7873386 |
1995 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evaluation of the clinical relevance of the anionic glutathione-s-transferase (GST pi) and multidrug resistance (mdr-1) gene coexpression in leukemias and lymphomas.
|
7874003 |
1994 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression dynamics of drug resistance genes, multidrug resistance 1 (MDR1) and lung resistance protein (LRP) during the evolution of overt leukemia in myelodysplastic syndromes.
|
16566920 |
2006 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of 10 U or more of mdr1 was found in 6 of 31 (19%) leukemias at diagnosis, versus 5 of 10 (50%) after relapse from therapy, P = .06.
|
1859877 |
1991 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Expression of the human multidrug resistance 1 gene (MDR1), which encodes the P-glycoprotein transmembrane efflux pump, has been associated with treatment failure of some leukemias, primarily acute myeloid leukemia (AML).
|
10360380 |
1999 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glutathione-s-transferase pi expression in leukaemia: a comparative analysis with mdr-1 data.
|
2386736 |
1990 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High mdr1- and mrp-, but low topoisomerase II alpha-gene expression in B-cell chronic lymphocytic leukaemias.
|
7954350 |
1994 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, MDR1 expression in CD7+ AML/ALL might be responsible for the poor response to conventional chemotherapies of these types of leukemia.
|
7694687 |
1993 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In an immunocytochemical study we have looked at a selection of B-cell leukaemias for mdr-1 and mdr-3 encoded Pgp expression using monoclonal antibodies specific for the mdr-1 and mdr-3 encoded gene products.
|
10500781 |
1999 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, expression of mdr1 RNA is common in acute untreated leukaemia.
|
1380280 |
1992 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, there is evidence that the pattern of MDR1 expression observed in leukemias reflects the distribution of MDR1 in normal hematopoiesis.
|
7540457 |
1995 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these results suggested that the MDR1 TT genotype might influence risk of development of acute lympoblastic leukemia and the CC genotype might be linked to a poor prognosis of ALL.
|
21133625 |
2010 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, it had no effect on P-glycoprotein-mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells and multidrug resistance-related protein 1-mediated doxorubicin resistance in MRP1-transfected human epidermoid cancer KB-3-1 cells.
|
21566063 |
2011 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, an idarubicin plus short-course cyclosporin A combination could be considered for the management of MDR1+ leukemias, where it may represent a more effective and less toxic option than daunorubicin plus continuous infusion cyclosporin A.
|
10342576 |
1999 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the tumor-bearing nude mice, anti-tumor drugs vincristine, daunorubicin (DNR), STI571, and STI571 plus VCR for the treatment of mdr1 and bcr/abl double positive leukemia were studied respectively.
|
16780770 |
2006 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this present study we have measured RNA levels of mdr1 and gst-pi in primary human breast tumour biopsies prior to chemotherapy and from tumours which have different inherent responses to doxorubicin treatment, including colon, head and neck squamous cell carcinomas and myeloid leukaemias.
|
1970934 |
1990 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this report, we describe a novel G571A variant of MDR1 detected in 6.4% of leukemia patients.
|
18723777 |
2008 |
|
leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In this review, we cover the current information and postulate that epigenetic modification of MDR1 chromatin influences gene transcription in leukaemia.
|
14567978 |
2003 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased expression and amplification of mdr1 sequences were also found in multidrug-resistant sublines of human leukemia and ovarian carcinoma cells.
|
3457471 |
1986 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Induction of MDR1 gene expression by anthracycline analogues in a human drug resistant leukaemia cell line.
|
10070877 |
1999 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Low levels of MDR1 expression were found by polymerase chain reaction in most solid tumors and leukemias tested.
|
1976252 |
1990 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
No relationship was found between MDR1 RNA levels and FAB type of leukaemia or patient age.
|
1696833 |
1990 |