|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
P-glycoprotein (P-gp)/multi-drug resistance 1 (MDR1) gene is recognized to be, at least in part, responsible for the refractoriness to chemotherapy of leukemia.
|
11734301 |
2002 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Resistance to purine and pyrimidine nucleoside and nucleobase analogs by the human MDR1 transfected murine leukemia cell line L1210/VMDRC.06.
|
15294454 |
2004 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Retroviral vector transduction of human leukemia cell lines expressing MDR1 was accomplished by co-culturing these with virus producer cells.
|
10362143 |
1999 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sequential emergence of MRP- and MDR1-gene over-expression as well as MDR1-gene translocation in homoharringtonine-selected K562 human leukemia cell lines.
|
8575859 |
1996 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since mdr1 and mdr3 are frequently expressed in untreated as well as treated leukemia, such combination therapy should be considered for untreated patients as well as treated patients.
|
1972761 |
1990 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since there is no consensus on the techniques for multidrug resistance (MDR) phenotype evaluation, many discrepancies concerning the importance and frequency of mdr1 gene expression in leukemias and solid tumors are observed in the literature.
|
9204997 |
1997 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The MDR1 expression rate was significantly correlated with factors such as a history of preceding chemotherapy, elder age of the patient, and certain disease types (eg, leukemia progressed from myelodysplastic syndrome).
|
10695666 |
2000 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between the MDR1 G2677T polymorphism and leukemia risk was conducted by odds ratios (ORs) and 95% confidence intervals (95% CI).
|
24142546 |
2014 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cytotoxic studies have demonstrated a higher sensitivity of the leukemia lines to DOX-BNNPs compared with the carcinoma lines: IC<sub>50</sub>(DOX-BNNPs) is 1.13, 4.68, 0.025, and 0.14 μg/mL for the KB-3-1, MDR KB-8-5, K562, and MDR i-S9 cell lines, respectively.
|
28857548 |
2017 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The fortuitous inhibition of MDR-1 expression in t(8;21)-containing leukemias may contribute to the favorable response of these patients to chemotherapeutic drugs.
|
9584201 |
1998 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The multidrug resistance gene, MDR1, is one of the genes responsible for resistance to chemotherapy in the treatment of leukaemia and other cancers.
|
17909680 |
2007 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The process behind the expression of mdr-1/P-gp and mrp/MRP in human leukemia/lymphoma.
|
19414348 |
2009 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that siRNA specifically and efficiently interferes with the expression of mdr1 and could be used as a molecularly defined therapeutic approach for MDR in the treatment of leukemia.
|
15375375 |
2004 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings provide further evidence that the MDR1 C3435T variant may modify the susceptibility to leukemia.
|
22088099 |
2012 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that MDR1 gene expression is correlated with the leucocyte differentiation stage of leukemia.
|
8477061 |
1993 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that MDR1-AS is useful to overcome multidrug resistance in the treatment of leukemia.
|
9558371 |
1998 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These may include increased production of tumor resistance conferring proteins such as multidrug resistance (MDR-1) and myeloid cell leukemia (MCL-1).
|
30452910 |
2019 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that the MDR1 C3435T polymorphism associate with risk of leukaemia.
|
23731124 |
2013 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To overcome P-gp-mediated drug resistance, we have developed six anti-MDR1 hammerhead ribozymes and delivered them to P-gp-overproducing human leukemia cell line by a retroviral vector containing RNA polymerase III promoter.
|
11774737 |
2001 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To understand the mechanism that underlies the emergence of cells with such gene alterations in human leukemia, we performed clonal analysis of the gene expression of mutant dihydrofolate reductase (DHFR) and mdr1 in trimetrexate-resistant human leukemia MOLT-3 cells.
|
10360822 |
1999 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Treatment of leukaemia cells with 3p-siRNA-MDR1 down-regulated MDR1 expression, reduced-drug resistance and induced immune and pro-apoptotic effects in drug-resistant HL-60/Adr and K562/Adr human leukaemia cell lines.
|
28380403 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment of multidrug resistant (MDR1) murine leukemia with P-glycoprotein substrates accelerates the course of the disease.
|
10581184 |
1999 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We examined the expression of the mdr1 gene in 90 human tumor cell lines of which 79 were derived from leukemia or lymphoma samples.
|
8099136 |
1993 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have established competitive reverse transcriptase polymerase chain reaction (RT-PCR) assay for the quantification of MDR1 mRNA encoding P-glycoprotein (P-gp) by analyzing leukemia sublines of MOLT-3 with various expression of MDR1.
|
9292393 |
1997 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have identified a novel MDR1 (GT1292-3TG) (Cys431Leu) genetic variation through systematic profiling of subjects with leukemia.
|
20623213 |
2010 |