|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
HT29 MDR-1 negative cells produce undifferentiated signet ring carcinomas when implanted subcutaneously into SCID mice, while HT29 MDR-1 positive cells form tumors with tubular structures, but without signet ring cells.
|
22154301 |
2012 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Using a case-control design, the association between the MDR1 intron 3 G-rs3789243-A polymorphism and the risk of colorectal carcinomas and adenomas in the Norwegian population was assessed in 167 carcinomas, 990 adenomas, and 400 controls.
|
19250544 |
2009 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Prognostic significance of multidrug-resistance protein (MDR-1) in renal clear cell carcinomas: a five year follow-up analysis.
|
17177989 |
2006 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast to the up-regulated expression of MDR1, the expression of LRP tended to be down-regulated in carcinomas.
|
15379935 |
2004 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In patients with primary FIGO III carcinomas (n = 18), the overall-survival time (OST) was significantly prolonged with low MDR1/P-gp expression level (P = 0.015).
|
15262134 |
2004 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Amplification of the mdr1-gene has been observed in tumor cell lines exposed to cytotoxic drugs; however, significant information is lacking as to whether this holds true in clinical carcinomas.
|
10656626 |
1999 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Sections from specimens of gastric carcinomas were immunohistochemically stained to detect P-glycoprotein (which is associated with MDR-1 expression).
|
10446694 |
1999 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Because P-glycoprotein expression might be associated with a more aggressive behaviour of colorectal carcinomas (Weinstein et al., Cancer Res, 1991, 51, 2720-2726), we determined the relationship between MDR1 RNA expression of the carcinomas and the survival of the patients.
|
9337699 |
1997 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
MDR1 RNA was detected in 80 (60%) of the carcinomas.
|
9816292 |
1996 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MDR1 expression was detectable, albeit at low levels, in 8 of the 11 tumors, suggesting a possible role of this gene in the drug resistance of prostate carcinomas.
|
7904313 |
1994 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Antibody and complementary DNA probes utilized for detection of the MDR1 gene product and mRNA levels, respectively, revealed that prior to drug treatment the lung tumor had virtually no detectable P-glycoprotein while both colon carcinomas displayed low and heterogeneous expression of this resistance-related protein.
|
7915508 |
1994 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MDR1 RNA was detected in 41% of the gastric carcinomas, with high levels in 18% of the specimens.
|
8431845 |
1993 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
MDR1 RNA was detected in 65% of the carcinomas.
|
8398695 |
1993 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This study was designed to measure the MDR1 messenger RNA (mRNA) content of ovarian and lung carcinomas and to analyze clinical correlations of MDR1 expression in these tumors.
|
1359152 |
1992 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In 59 evaluable patients with primary breast carcinomas, MDR1 RNA levels of the carcinomas were negative in 54%, low in 29% and high in 17% of the patients.
|
1835847 |
1991 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, direct evidence that expression of the MDR1 gene contributes to the multidrug resistance of human liver carcinomas has not been established.
|
1676033 |
1991 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Of eight carcinomas treated by radiotherapy and/or chemotherapy, seven (88%) exhibited MDR1 transcripts as compared with 24 (35%) of 69 untreated carcinomas (Fisher's exact test; P = .01).
|
1697346 |
1990 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results imply that the higher levels of MDR1 mRNA found in well-differentiated carcinomas derived from colorectal tissues are the results of increased expression of the MDR1 gene in the luminal surface cells.
|
1977924 |
1990 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Using the DNA fragment from normal tissues rather than KB cells, we have reanalyzed MDR1 mRNA levels in 12 renal carcinomas and 4 colon adenocarcinomas.
|
2481665 |
1989 |