TBC1D9, TBC1 domain family member 9, 23158

N. diseases: 491; N. variants: 11
Disease: Colitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009319
Disease: Colitis
Colitis 		0.040 Biomarker disease BEFREE Exogenous induction of mROS accelerates, while inhibition attenuates colitis in vivo; these effects are amplified in MDR1 deficiency. 28401939 2018
CUI: C0009319
Disease: Colitis
Colitis 		0.040 PosttranslationalModification disease BEFREE MDR1 methylation occurred more frequently in total colitis, and total+left side colitis, compared to rectal colitis (p=0.001, 0.013, respectively). 19288029 2009
CUI: C0009319
Disease: Colitis
Colitis 		0.040 Biomarker disease BEFREE Perhaps the greatest piece of evidence of the physiological importance of P-gp in the G-I tract has come from the description of the mdr1 knock-out mice model, which develops a spontaneous colitis in a specific pathogen-free environment. 16773678 2006
CUI: C0009319
Disease: Colitis
Colitis 		0.040 Biomarker disease BEFREE Because mdr1 knockout mice spontaneously develop colitis, exonic regions were resequenced and tested for IBD association in a large, multicenter North American cohort. 14610718 2003