|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whereas wild-type Teff cells upregulated Mdr1 in the ileum, those lacking Mdr1 displayed mucosal dysfunction and induced Crohn's disease-like ileitis following transfer into Rag1<sup>-/-</sup> hosts.
|
29262351 |
2017 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated whether SNPs in MDR1 are associated with CD in Algerian pediatric patients.
|
27603561 |
2016 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of MDR1 are associated with patient's GC response and a predisposition to CD in Chinese population.
|
25346426 |
2015 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Besides, stratified analysis by clinical type also indicated that no significant association between MDR1 C3435T and the risk of Crohn's disease and ulcerative colitis was observed.
|
24449364 |
2014 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MDR1 polymorphisms are associated with both CD and UC with a stronger association with UC.
|
23537364 |
2013 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The expression level of the ABCB1/MDR1 gene which encodes P-glycoprotein seems to be of great prognostic relevance while evaluating patients' susceptibility to UC or CD.
|
22661185 |
2012 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether DNA variants in the MDR1 gene were associated with susceptibility for CD and specific phenotypes in children.
|
19107781 |
2009 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism located in intron 3 of the MDR1 gene showed a weak association with CD, and a marginally suggestive association with UC.
|
18819034 |
2009 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MDR1 polymorphisms and response to azathioprine therapy in patients with Crohn's disease.
|
17262810 |
2007 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three hundred eighty-eight German IBD patients [244 with Crohn's disease (CD), 144 with ulcerative colitis (UC)] and 1,005 German healthy controls were genotyped for the two MDR1 SNPs on positions 2677G>T/A and 3435C>T.
|
17665184 |
2007 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant association was found between the MDR1 C3435T polymorphism and patients with ileo-colonic CD (OR = 3.34; 95% CI: 1.34-8.27).
|
17260353 |
2007 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In our pediatric cohort, the promoter -308A polymorphism of TNF-alpha but not the MDR1 gene is significantly involved in the predisposition to both CD and UC.
|
17255827 |
2007 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
This 'candidate gene' approach provides compelling evidence to support the contribution of the ABCB1/MDR1 gene in determining risk to UC but not to CD and provides new insights into the localization of the critical susceptibility determinants within the gene.
|
16434479 |
2006 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, considering our results and those from others, the MDR1 gene behaves as a common risk factor for both CD and UC.
|
16374256 |
2006 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis.
|
15505619 |
2004 |
|
Crohn Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Relative amounts of MDR1 mRNA expressed in peripheral blood mononuclear cells (PBMCs) were measured using the reverse-transcriptase polymerase chain reaction (RT-PCR) technique in 25 UC patients having no history of GC administration, 25 UC patients having experienced GC therapy, 19 patients with Crohn's disease (CD) with no history of GC therapy, and 27 healthy subjects.
|
15102868 |
2004 |