|
Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Further, for NF-κB p65, MDR1, P-gp and apoptosis-associated protein levels detection, miR-542-3p mimic showed a suppressive effect on these KA-induced protein levels, whereas TLR4 overexpression ameliorated the miR-542-3p-induced these protein levels in KA-treated epilepsy rats.
|
31702493 |
2019 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
C3435T polymorphism of MDR1 gene was analysed by the high resolution melting technique in a group of patients with drug-resistant (n = 106) and drug-responsive epilepsy (n = 67), as well as in non-epileptic children (n = 98) hospitalised at the Department of Neurology, Polish Mother's Memorial Hospital in Lodz.
|
27391700 |
2016 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous studies reported the associations between the ATP-binding cassette sub-family B member 1 (ABCB1, also known as MDR1) polymorphisms and their haplotypes with risk of response to antiepileptic drugs in epilepsy, however, the results were inconclusive.
|
25816099 |
2015 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings rule out the MDR1 c.3435C>T polymorphism having a major role or increasing the risk of drug-resistance suggesting a revision is required to determine the contribution of this polymorphism in predicting drug response in epilepsy.
|
25458099 |
2015 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
All the case-control association researches evaluating the role of MDR1 C3435T polymorphism in childhood epilepsy to antiepileptic drugs were identified.
|
24553780 |
2014 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study does not support any significant association between the MDR1 polymorphism and drug-resistant childhood epilepsy.
|
23465586 |
2014 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the relationship between C3435T polymorphism of the MDR1 gene and drug resistance in epilepsy with the consideration of 4 different criteria for qualification to groups sensitive and resistant to applied pharmacotherapy.
|
25223475 |
2014 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To clarify the exact clinical implication of the MDR1 polymorphisms on the multidrug resistance in epilepsy, further investigations in various ethnic populations would be necessary.
|
24213830 |
2014 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The analysis showed that there were significantly more cases with the MDR1 3435 CC genotype in the group with drug-resistant epilepsy than in the group with drug-responsive epilepsy [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.06, P=0.01].
|
24953225 |
2014 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significance of MDR1 gene polymorphism C3435T in predicting drug response in epilepsy.
|
24300029 |
2014 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The study failed to corroborate association between polymorphism CYP3A5*3 and C3435T polymorphism in MDR1 gene and pharmacoresistant epilepsy.
|
23984379 |
2013 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, the authors investigated the association between the MDR1 gene polymorphisms, C3435T and G2677AT, and drug resistance epilepsy by using polymerase chain reaction/restriction fragment length polymorphism and pyrosequencing methods in a group of 39 patients with drug-resistant epilepsy and 92 controls.
|
20448249 |
2010 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to investigate the effect of the 1236C>T(rs1128503), 2677G>T/A(rs2032582), and 3435C>T(rs1045642) single-nucleotide polymorphisms of ABCB1 (or MDR1) on drug resistance in north Indian patients with epilepsy.
|
18812236 |
2009 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study did not support any significant association between the MDR1 (C3435T) polymorphism and resistance to CBZ in epilepsy patients from Turkey.
|
17917461 |
2008 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between C3435T nucleotide MDR1 genetic polymorphism and multidrug-resistant epilepsy.
|
16542858 |
2006 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three SNPs at nucleotide position 1236 in exon 12, 2677 in exon 21 and 3435 in exon 26 of the MDR1 gene were genotyped in 207 Korean epileptics.
|
16386926 |
2006 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Conflicting reports suggest a possible association between variants of the MDR1 gene and medical intractability in epilepsy.
|
15679503 |
2005 |
|
Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study failed to corroborate a previously reported association between the C3435T polymorphism in the human MDR1 gene and pharmacoresistant epilepsy.
|
15857428 |
2005 |
|
Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has therefore been proposed that MDR1/PgP may contribute to multiple drug resistance in epilepsy.
|
12699350 |
2003 |