Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multidrug resistance (MDR1) represents a major obstacle in the chemotherapeutic treatment of acute leukemia (AL).
|
24804815 |
2014 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results showed the potential clinical relevance of MDR1, MRP1 and BCL-2 in adult patients with acute leukemia in the context of induction chemotherapy.
|
22037714 |
2012 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India.
|
21133625 |
2010 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prognostic significance of multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression in acute leukemia.
|
16614510 |
2006 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest the efficacy of this quantitative analysis of MDR1 transcripts for the prediction of clinical drug resistance in acute leukemia.
|
12028995 |
2002 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this article, we review the different methods for determining MDR and, in particular, methods for determining P-gp/MDR1, with special reference to their potential importance for therapeutic strategies in human acute leukemia.
|
11185984 |
2000 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MDR1/P-GP expression as a prognostic factor in acute leukemias.
|
10500774 |
1999 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that MDR1 gene expression can be used as a prognostic factor and may be helpful in determining chemotherapeutic protocol for patients with acute leukemia.
|
9886170 |
1998 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It may be speculated that precytotoxic agents induced mdr1 and mdr3 P-gp expression in acute leukemia; however, in chronic leukemia, both P-gps were expressed independently of exposure to precytotoxic agents.
|
9150348 |
1997 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Multidrug resistance (Mdr1) gene expression in peripheral blasts from patients with acute leukemia only rarely increases during disease progression after combination chemotherapy.
|
8528050 |
1995 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Analysis of MDR1 and MDR3 multidrug resistance gene expression and amplification in consecutive samples in patients with acute leukaemias.
|
8574159 |
1995 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Multidrug resistance gene (mdr1) RNA levels in relation to P-glycoprotein content of leukemic cells from patients with acute leukemia.
|
8535665 |
1995 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prognostic value of rhodamine-efflux and MDR-1/P-170 expression in childhood acute leukemia.
|
8632662 |
1995 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) was used to investigate and compare transcription levels of the human multidrug resistance gene (MDR1) and the recently described multidrug resistance-associated protein (MRP) in 105 samples from patients with acute leukaemia at presentation and relapse.
|
7808005 |
1994 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thirteen out of 16 (81%) MDR-1 positive patients developed acute leukemia versus two of ten (20%) MDR-1 negative patients (p = 0.025).
|
8100604 |
1993 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MDR1 gene expression may, in part, explain the responsiveness to chemotherapy in these distinct subtypes of acute leukemia.
|
8477061 |
1993 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Quantitative determination of mdr1 gene expression in leukaemic cells from patients with acute leukaemia.
|
1380280 |
1992 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Investigations of mdr1 regulation in normal hematopoietic elements has shown a pattern which corresponds to its regulation in acute leukemia, explaining the linkage of mdr1 to specific cellular phenotypes.
|
1283551 |
1992 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that mdr1 expression contributes to chemoresistance in acute leukemia.
|
1859877 |
1991 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, P-glycoprotein expression and mdr1 gene amplification occurred infrequently not only in leukemia cells at the initial presentation but also in those at the relapsed cases and may not be a major cause of refractoriness to antileukemia drugs in adult acute leukemia.
|
2564311 |
1989 |