|
Drug Resistant Epilepsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate the expression levels of multidrug resistance gene 1 (MDR1), multidrug resistance-associated protein 1 (MRP1) and multidrug resistance P-glycoprotein (P-gp) in peripheral blood of patients with refractory epilepsy.
|
29318116 |
2018 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The reported study was designed to explore associations between the MDR1-C3435T gene SNP and the risk of DRE in the Polish population.
|
27534401 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
G2677T/A polymorphism of MDR1 may play a significant role in the development of DRE in the Polish patients.
|
28608314 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The relationship between the MDR1 C3435T polymorphism and childhood refractory epilepsy needs further validation.
|
28284049 |
2017 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presented studies analysed the association between C3435T polymorphism of MDR1 gene and the incidence of drug-resistant epilepsy in the population of Polish children.
|
27391700 |
2016 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HIF-1α may have a regulatory effect on MDR1 expression in refractory epilepsy, which is probably consistent with MDR mechanism in tumor.
|
24590840 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multidrug resistance 1 (MDR1) 3435C/T genotyping in childhood drug-resistant epilepsy.
|
23465586 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The obtained results clearly confirm the lack of a connection between the occurrence of drug-resistant epilepsy and C435T polymorphism of the MDR1 gene irrespective of the definition of drug resistance applied to the patient.
|
25223475 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess the association between MDR1 C3435T polymorphism and the response to anticonvulsants in childhood intractable epilepsy, we conducted a systematic review and meta-analysis.
|
24553780 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The relationship established in a subset of the Chinese population between the MDR1 C3435T polymorphism and refractory epilepsy will guide epilepsy treatment and development of new AEDs.
|
24953225 |
2014 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CYP3A5*3 and C3435T MDR1 polymorphisms in prognostication of drug-resistant epilepsy in children and adolescents.
|
23984379 |
2013 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No associations were found between the polymorphisms of the MDR1 gene and drug-resistant epilepsy.
|
20448249 |
2010 |
|
Drug Resistant Epilepsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Controversy has surrounded the reported association of the single nucleotide polymorphism (SNP) C3435T of the ATP-binding cassette subfamily B member 1 (ABCB1, MDR1) gene, with refractory epilepsy.
|
17125969 |
2007 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Twenty-six patients (15 males, 11 females, age range 4-25 years, mean age 22.92 years, SD 11.19 years) with intractable epilepsy were included in this study; the clinical characteristics were considered, and the pathological changes as well as expression of MDR1 and GFAP in surgically removed brain tissues of each subject were examined under light and electron microscopy.
|
16998727 |
2006 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Neuronal MDR-1 gene expression and persistent low levels of anticonvulsants in a child with refractory epilepsy.
|
14749549 |
2004 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both MDR1 gene expression and persistently low phenytoin levels likely share a common pathway liable to induce drug-resistant epilepsy.
|
10580886 |
1999 |
|
Drug Resistant Epilepsy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MDR1 expression is increased in brain of some patients with medically intractable epilepsy, suggesting that the patients' lack of response to medication may be caused by inadequate accumulation of AED in brain.
|
8001500 |
1995 |