Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These may include increased production of tumor resistance conferring proteins such as multidrug resistance (MDR-1) and myeloid cell leukemia (MCL-1).
|
30452910 |
2019 |
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cytotoxic studies have demonstrated a higher sensitivity of the leukemia lines to DOX-BNNPs compared with the carcinoma lines: IC<sub>50</sub>(DOX-BNNPs) is 1.13, 4.68, 0.025, and 0.14 μg/mL for the KB-3-1, MDR KB-8-5, K562, and MDR i-S9 cell lines, respectively.
|
28857548 |
2017 |
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between the MDR1 G2677T polymorphism and leukemia risk was conducted by odds ratios (ORs) and 95% confidence intervals (95% CI).
|
24142546 |
2014 |
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings provide further evidence that the MDR1 C3435T variant may modify the susceptibility to leukemia.
|
22088099 |
2012 |
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bortezomib is a promising potential therapy for acute leukemia, especially mdr1 drug-resistant leukemia.
|
22145750 |
2012 |
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, it had no effect on P-glycoprotein-mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells and multidrug resistance-related protein 1-mediated doxorubicin resistance in MRP1-transfected human epidermoid cancer KB-3-1 cells.
|
21566063 |
2011 |
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these results suggested that the MDR1 TT genotype might influence risk of development of acute lympoblastic leukemia and the CC genotype might be linked to a poor prognosis of ALL.
|
21133625 |
2010 |
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have identified a novel MDR1 (GT1292-3TG) (Cys431Leu) genetic variation through systematic profiling of subjects with leukemia.
|
20623213 |
2010 |
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The process behind the expression of mdr-1/P-gp and mrp/MRP in human leukemia/lymphoma.
|
19414348 |
2009 |
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this report, we describe a novel G571A variant of MDR1 detected in 6.4% of leukemia patients.
|
18723777 |
2008 |
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression dynamics of drug resistance genes, multidrug resistance 1 (MDR1) and lung resistance protein (LRP) during the evolution of overt leukemia in myelodysplastic syndromes.
|
16566920 |
2006 |
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We recently discovered a novel G --> T variant at 1199 nucleotide position of MDR1 which exhibits a 2.3% allelic frequency in leukemia patients.
|
16917872 |
2006 |
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the tumor-bearing nude mice, anti-tumor drugs vincristine, daunorubicin (DNR), STI571, and STI571 plus VCR for the treatment of mdr1 and bcr/abl double positive leukemia were studied respectively.
|
16780770 |
2006 |
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that siRNA specifically and efficiently interferes with the expression of mdr1 and could be used as a molecularly defined therapeutic approach for MDR in the treatment of leukemia.
|
15375375 |
2004 |
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Resistance to purine and pyrimidine nucleoside and nucleobase analogs by the human MDR1 transfected murine leukemia cell line L1210/VMDRC.06.
|
15294454 |
2004 |
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models.
|
12609962 |
2003 |
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
P-glycoprotein (P-gp)/multi-drug resistance 1 (MDR1) gene is recognized to be, at least in part, responsible for the refractoriness to chemotherapy of leukemia.
|
11734301 |
2002 |
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To overcome P-gp-mediated drug resistance, we have developed six anti-MDR1 hammerhead ribozymes and delivered them to P-gp-overproducing human leukemia cell line by a retroviral vector containing RNA polymerase III promoter.
|
11774737 |
2001 |
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The MDR1 expression rate was significantly correlated with factors such as a history of preceding chemotherapy, elder age of the patient, and certain disease types (eg, leukemia progressed from myelodysplastic syndrome).
|
10695666 |
2000 |
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although innumerable reports have been published in which P-gp has been shown to confer MDR to malignant (including leukemia) cells, so far, large-scale studies in the clinical setting have not convincingly proven that MDR1 plays a major role in clinical drug resistance when the influence of other known prognostic factors in human leukemia are taken into account.
|
11185984 |
2000 |
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Retroviral vector transduction of human leukemia cell lines expressing MDR1 was accomplished by co-culturing these with virus producer cells.
|
10362143 |
1999 |
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To understand the mechanism that underlies the emergence of cells with such gene alterations in human leukemia, we performed clonal analysis of the gene expression of mutant dihydrofolate reductase (DHFR) and mdr1 in trimetrexate-resistant human leukemia MOLT-3 cells.
|
10360822 |
1999 |
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment of multidrug resistant (MDR1) murine leukemia with P-glycoprotein substrates accelerates the course of the disease.
|
10581184 |
1999 |
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that MDR1-AS is useful to overcome multidrug resistance in the treatment of leukemia.
|
9558371 |
1998 |
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have established competitive reverse transcriptase polymerase chain reaction (RT-PCR) assay for the quantification of MDR1 mRNA encoding P-glycoprotein (P-gp) by analyzing leukemia sublines of MOLT-3 with various expression of MDR1.
|
9292393 |
1997 |