|
Adult Glioblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10(-4))) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10(-7)); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10(-3)); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)).
|
21350045 |
2011 |
|
Alkaline phosphatase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To assess the associations between SNPs in the FAM13A, PHLDB1, and CYP24A1 gene and breast cancer risk in the Chinese Han population.
|
31215377 |
2019 |
|
Celiac Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci.
|
25920553 |
2016 |
|
Central Nervous System Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study identifies five susceptibility loci for glioma.
|
19578367 |
2009 |
|
Central Nervous System Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
Central Nervous System Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
Central Nervous System Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
|
Childhood Glioblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10(-4))) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10(-7)); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10(-3)); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)).
|
21350045 |
2011 |
|
Chromosome 10, monosomy 10q
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
rs2736100 (TERT) and rs6010620 (RTEL1) risk alleles were associated with high-grade disease, EGFR amplification, CDKN2A-p16-INK4a homozygous deletion, and 9p and 10q deletion; rs4295627 (CCDC26) and rs498872 (PHLDB1) were associated with low-grade disease, IDH mutation, and 1p-19q codeletion.
|
23161787 |
2013 |
|
Glioblastoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We also observed that the GA genotype of the rs498872 (PHLDB1) was associated with an increased risk of gliomas (OR 2.92) and glioblastomas (OR 2.39).
|
31721021 |
2020 |
|
Glioblastoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10(-4))) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10(-7)); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10(-3)); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)).
|
21350045 |
2011 |
|
Glioblastoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The variant TT genotype of TREH rs17748 and the variant TT genotype of PHLDB1 rs498872 decreased GBM risk in the recessive model.
|
26156397 |
2015 |
|
Glioblastoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Results showed clear heterogeneity according to histologic subtypes of glioma, with TERT and RTEL variants a feature of astrocytic tumors and glioblastoma (GBM), CCDC26 and PHLDB1 variants a feature of astrocytic and oligodendroglial tumors, and CDKN2B variants most prominent in GBM.
|
21203894 |
2011 |
|
Glioblastoma Multiforme
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The variant TT genotype of TREH rs17748 and the variant TT genotype of PHLDB1 rs498872 decreased GBM risk in the recessive model.
|
26156397 |
2015 |
|
Glioblastoma Multiforme
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Results showed clear heterogeneity according to histologic subtypes of glioma, with TERT and RTEL variants a feature of astrocytic tumors and glioblastoma (GBM), CCDC26 and PHLDB1 variants a feature of astrocytic and oligodendroglial tumors, and CDKN2B variants most prominent in GBM.
|
21203894 |
2011 |
|
Glioblastoma Multiforme
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10(-4))) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10(-7)); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10(-3)); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)).
|
21350045 |
2011 |
|
Glioma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility.
|
26610392 |
2015 |
|
Glioma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our data strongly support PHLDB1 as a susceptibility gene for glioma, also shedding light on a new potentially candidate gene, ARCN1.
|
23300798 |
2012 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The PHLDB1 rs498872 (11q23.3) polymorphism and glioma risk: A meta-analysis.
|
24935770 |
2015 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)).
|
19578367 |
2009 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case-control studies, and 1 population-based case-only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and consistent association signals for the remaining four at 7p11.2 (EGFR both loci), 8q24.21 (CCDC26) and 11q23.3 (PHLDB1).
|
22886559 |
2012 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the association with glioma risk for variants within five genomic regions: 8q24.21 (CCDC26), 9p21.3 (CDKN2B-AS1), 11q23.3 (PHLDB1), 17p13.1 (TP53), and 20q13.33 (RTEL1).
|
25713050 |
2015 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study found that PHLDB1 rs498872 polymorphism was significantly associated with glioma risk in Chinese Han population.
|
28886307 |
2017 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Specific single nucleotides polymorphisms (SNPs) rs4977756 (CDKN2A/B), rs6010620 (RTEL1), rs498872 (PHLDB1), rs2736100 (TERT), and rs4295627 (CCDC26) have been associated with glioma susceptibility and are potential risk biomarkers.
|
31721021 |
2020 |