|
Chromosome 10, monosomy 10q
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
rs2736100 (TERT) and rs6010620 (RTEL1) risk alleles were associated with high-grade disease, EGFR amplification, CDKN2A-p16-INK4a homozygous deletion, and 9p and 10q deletion; rs4295627 (CCDC26) and rs498872 (PHLDB1) were associated with low-grade disease, IDH mutation, and 1p-19q codeletion.
|
23161787 |
2013 |
|
Nasopharyngeal carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
|
20512145 |
2010 |
|
IGA Glomerulonephritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
As a result, NTN4 rs1362970 A/A and GNG2 rs3204008 G/G genotypes were associated with enhanced IgAN risk in males (p = 0.006, p = 0.023, respectively), and the association between the PHLDB1 rs7389 G/T genotype and higher IgAN risk was found in females (p = 0.008).
|
30928649 |
2019 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
Central Nervous System Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
Celiac Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci.
|
25920553 |
2016 |
|
Primary sclerosing cholangitis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.
|
23603763 |
2013 |
|
Serum total cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Discovery and refinement of loci associated with lipid levels.
|
24097068 |
2013 |
|
Serum total cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Discovery and refinement of loci associated with lipid levels.
|
24097068 |
2013 |
|
Glioma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility.
|
26610392 |
2015 |
|
Alkaline phosphatase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Serum total cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk.
|
20462933 |
2010 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1).
|
23161787 |
2013 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk.
|
20847058 |
2010 |
|
mixed gliomas
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies five susceptibility loci for glioma.
|
19578367 |
2009 |
|
Malignant Glioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies five susceptibility loci for glioma.
|
19578367 |
2009 |
|
Central Nervous System Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study identifies five susceptibility loci for glioma.
|
19578367 |
2009 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
|
Central Nervous System Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
Central Nervous System Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study found that PHLDB1 rs498872 polymorphism was significantly associated with glioma risk in Chinese Han population.
|
28886307 |
2017 |
|
Glioma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our data strongly support PHLDB1 as a susceptibility gene for glioma, also shedding light on a new potentially candidate gene, ARCN1.
|
23300798 |
2012 |