|
Fetal Growth Retardation
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
We aimed to classify placental dysfunction in preeclampsia and fetal growth restriction at delivery by metabolic profiling and authenticate the biomarker Flt-1 for placental dysfunction.
|
31495279 |
2019 |
|
Fetal Growth Retardation
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Effects of Folic Acid on DNMT1, GAP43, and VEGFR1 in Intrauterine Growth Restriction Filial Rats.
|
28639476 |
2018 |
|
Fetal Growth Retardation
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF).
|
28494189 |
2017 |
|
Fetal Growth Retardation
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
In 167 patients divided into four groups, three of those with early PE, late PE and IUGR and one control group, fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), high sensitive c-reactive protein (hsCRP) and fibronectin were determined.
|
27865093 |
2017 |
|
Fetal Growth Retardation
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
The aim of this study was to determine the transcriptional activity of individual pro- and anti-angiogenic markers (VEGF, HIF-1, sEng, Flt-1, PlGF-1) in maternal blood samples from patients with spontaneous preterm labor, preterm labor in combination with pre-eclampsia and fetal growth restriction in comparison with physiologically terminated pregnancies.
|
28429366 |
2017 |
|
Fetal Growth Retardation
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
The Flt-1 mRNA expression in maternal blood can be used as a marker to predict the development of FGR, long before a clinical diagnosis is made.
|
25491486 |
2015 |
|
Fetal Growth Retardation
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
In the animal experiment there was no significant difference in sFlt-1 between treatment group and FGR group without treatment or control group (P>0.05).
|
25149383 |
2014 |
|
Fetal Growth Retardation
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The aim of the study was to investigate the expression of genes coding for vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) as well as their receptors, fms-like tyrosine kinase receptor 1 (VEGFR-1/Flt-1) and VEGF receptor 2 (VEGFR-2/KDR) in the placentae of patients with pregnancies complicated by preeclampsia (PE) and intrauterine growth restriction (IUGR).
|
23719118 |
2013 |
|
Fetal Growth Retardation
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
Many genes that are known to be up-regulated in pre-eclampsia are also up-regulated in FGR, including the anti-angiogenic factors, FLT1 and ENG, believed to be associated with the onset of maternal symptoms of pre-eclampsia.
|
21810232 |
2011 |
|
Fetal Growth Retardation
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
Placental expression of soluble fms-like tyrosine kinase 1 is increased in singletons and twin pregnancies with intrauterine growth restriction.
|
17956955 |
2008 |
|
Fetal Growth Retardation
|
0.200 |
AlteredExpression
|
phenotype |
LHGDN |
Placental expression of soluble fms-like tyrosine kinase 1 is increased in singletons and twin pregnancies with intrauterine growth restriction.
|
17956955 |
2008 |
|
Fetal Growth Retardation
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The main objective of this study was to investigate hypoxia-inducible transcription factor-alpha (HIF-alpha) and downstream genes (VEGF receptor-1) Flt-1 and soluble fms-like tyrosine kinase 1 (sFlt-1) proteins in IUGR placentas.
|
17507435 |
2007 |
|
Fetal Growth Retardation
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The putative stimulus for increased sFlt-1 during preeclampsia, placental hypoxia due to poor perfusion, is common to both preeclampsia and idiopathic intrauterine growth restriction.
|
15886253 |
2005 |
|
Fetal Growth Retardation
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, alterations in VEGF, VEGFR-1 and VEGFR-2 mRNA expression, during the period of maximal placental growth, may contribute to the development of placental insufficiency, and ultimately intrauterine growth restriction.
|
11945079 |
2002 |
|
Fetal Growth Retardation
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Altered placental and circulating levels of vascular endothelial growth factor (VEGF) and its receptor (flt-1) may be associated with pre-eclampsia and intrauterine growth restriction (IUGR).
|
11675477 |
2001 |
|
Fetal Growth Retardation
|
0.200 |
Biomarker
|
phenotype |
HPO |
|
|
|