FLT1, fms related receptor tyrosine kinase 1, 2321

N. diseases: 424; N. variants: 33
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE These data suggest that VEGFR-1 up-regulation might contribute to melanoma progression and spreading after acquisition of a drug-resistant phenotype. 31758648 2020
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE The pharmacological inhibition of CYP4A reduced lung pre-metastatic niche formation (evidenced by a decrease in vascular endothelial growth factor receptor 1 positive (VEGFR1<sup>+</sup>) myeloid cell recruitment and pro-metastatic protein expression) and metastatic burden, accompanied with TAM polarization away from the M2 phenotype in spontaneous metastasis models of 4T1 breast cancer and B16F10 melanoma. 28481877 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE In this study we investigated whether PlGF and NRP-1 cooperate in promoting melanoma aggressiveness independently of VEGFR-1. 26846845 2016
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE The knockdown of VEGFR1 in three melanoma cell lines completely disrupts Matrigel-induced CLS formation, whereas inhibition of VEGFR2 kinase with a specific inhibitor, protein tyrosine kinase inhibitor II (PTKi-II), does not affect the process, indicating that VEGFR2 signaling is not involved in VEGFA-mediated melanoma VM. 21389833 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE In vivo, melanoma-specific shRNA-mediated knockdown of VEGFR-1 blocked the development of ABCB5(+) VM morphology and inhibited ABCB5(+) VM-associated production of the secreted melanoma mitogen laminin. 21212411 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE Placenta growth factor (PlGF) and its receptor vascular endothelial growth factor receptor-1 (VEGFR-1) are co-expressed in a large number of human melanoma cell lines. 21109946 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease CTD_human We found ERBB4 mutations in 19% of individuals with melanoma and found mutations in two other kinases (FLT1 and PTK2B) in 10% of individuals with melanomas. 19718025 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE We found ERBB4 mutations in 19% of individuals with melanoma and found mutations in two other kinases (FLT1 and PTK2B) in 10% of individuals with melanomas. 19718025 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Analyzing the contribution of progenitor-like cells during melanoma metastasis formation, we observed an enhanced proliferation and mobilization of VEGFR-1+ myeloid and VEGFR-2+ endothelial cells with progenitor potential by the induction of melanoma lung metastasis, which was not influenced by interference with VEGFR signaling. 17230507 2007
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease LHGDN Overproduction of VEGF concomitantly expressed with its receptors promotes growth and survival of melanoma cells through MAPK and PI3K signaling. 15610528 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease LHGDN Increased expression of VEGF-receptors (FLT-1, KDR, NRP-1) and thrombospondin-1 is associated with glomeruloid microvascular proliferation, an aggressive angiogenic phenotype, in malignant melanoma. 15166498 2003
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Expresson of vascular endothelial growth factor, its receptors (FLT-1, KDR) and TSP-1 related to microvessel density and patient outcome in vertical growth phase melanomas. 11438469 2001
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Model 2: Adflt-ExR was injected into pre-established B16 cell-induced eyelid malignant melanoma. 10937546 2000