ASTN2, astrotactin 2, 23245

N. diseases: 51; N. variants: 41
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338480
Disease: Common Migraine
Common Migraine 		0.410 Biomarker disease BEFREE MEF2D, PRDM16 and ASTN2 were also found to be associated with migraine without aura (MO) and migraine with family history. 28058730 2017
CUI: C0338480
Disease: Common Migraine
Common Migraine 		0.410 GeneticVariation disease GWASCAT Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. 27322543 2016
CUI: C0338480
Disease: Common Migraine
Common Migraine 		0.410 GeneticVariation disease GWASDB Genome-wide meta-analysis identifies new susceptibility loci for migraine. 23793025 2013
CUI: C0338480
Disease: Common Migraine
Common Migraine 		0.410 Biomarker disease CTD_human Genome-wide association analysis identifies susceptibility loci for migraine without aura. 22683712 2012
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.400 GeneticVariation disease GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745 2019
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.400 Biomarker disease CTD_human Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. 30374069 2018
CUI: C0029410
Disease: Osteoarthritis of hip
Osteoarthritis of hip 		0.400 GeneticVariation disease GWASCAT Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. 30374069 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 Biomarker disease BEFREE This iPSC line may be suitable for evaluating Astrotactin-2 function relevant for SCZ onset in the human brain. 29803967 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 Biomarker disease BEFREE ASTN2 has been implicated in several neuropsychiatric disorders, including cognitive disorders, autism and schizophrenia. 25410587 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 Biomarker disease PSYGENET The best associated SNP rs11789399 was located at 9q33.1 (p=2.38 × 10(-6), 5.74 × 10(-4), and 5.56 × 10(-9), for schizophrenia, bipolar disorder and meta-analysis of schizophrenia and bipolar disorder, respectively), where one flanking gene, ASTN2 (220kb away) has been associated with attention deficit/hyperactivity disorder and schizophrenia. 20889312 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 GeneticVariation disease BEFREE The best associated SNP rs11789399 was located at 9q33.1 (p=2.38 × 10(-6), 5.74 × 10(-4), and 5.56 × 10(-9), for schizophrenia, bipolar disorder and meta-analysis of schizophrenia and bipolar disorder, respectively), where one flanking gene, ASTN2 (220kb away) has been associated with attention deficit/hyperactivity disorder and schizophrenia. 20889312 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 Biomarker disease PSYGENET Among the genes disrupted by the remaining rare CNVs are MYT1L, CTNND2, NRXN1, and ASTN2, genes that play an important role in neuronal functioning but--except for NRXN1--have not been associated with schizophrenia before. 18940311 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.340 Biomarker disease BEFREE Among the genes disrupted by the remaining rare CNVs are MYT1L, CTNND2, NRXN1, and ASTN2, genes that play an important role in neuronal functioning but--except for NRXN1--have not been associated with schizophrenia before. 18940311 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.300 Biomarker disease PSYGENET The best associated SNP rs11789399 was located at 9q33.1 (p=2.38 × 10(-6), 5.74 × 10(-4), and 5.56 × 10(-9), for schizophrenia, bipolar disorder and meta-analysis of schizophrenia and bipolar disorder, respectively), where one flanking gene, ASTN2 (220kb away) has been associated with attention deficit/hyperactivity disorder and schizophrenia. 20889312 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.300 Biomarker disease CTD_human Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. 19404257 2009
CUI: C0236733
Disease: Amphetamine-Related Disorders
Amphetamine-Related Disorders 		0.300 Biomarker group CTD_human Genome-wide association for methamphetamine dependence: convergent results from 2 samples. 18316681 2008
CUI: C0236804
Disease: Amphetamine Addiction
Amphetamine Addiction 		0.300 Biomarker disease CTD_human Genome-wide association for methamphetamine dependence: convergent results from 2 samples. 18316681 2008
CUI: C0236807
Disease: Amphetamine Abuse
Amphetamine Abuse 		0.300 Biomarker disease CTD_human Genome-wide association for methamphetamine dependence: convergent results from 2 samples. 18316681 2008
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.300 GeneticVariation disease UNIPROT
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.130 GeneticVariation disease BEFREE None of the findings survived correction for multiple testing, thus, results do not support a major role of common variants in ASTN2 in the pathogenesis of ADHD, its comorbid disorders or ADHD associated personality traits. 27138430 2016
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.130 Biomarker disease BEFREE Deletions of the neuronal ASTN2 and the ASTN2-intronic TRIM32 genes yielded the strongest association with ADHD and ASD, but numerous other shared candidate genes (such as CHCHD3, MACROD2, and the 16p11.2 region) were also revealed. 21832240 2011
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.130 GeneticVariation disease BEFREE The best associated SNP rs11789399 was located at 9q33.1 (p=2.38 × 10(-6), 5.74 × 10(-4), and 5.56 × 10(-9), for schizophrenia, bipolar disorder and meta-analysis of schizophrenia and bipolar disorder, respectively), where one flanking gene, ASTN2 (220kb away) has been associated with attention deficit/hyperactivity disorder and schizophrenia. 20889312 2010
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.130 GeneticVariation disease GWASCAT Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. 18839057 2008
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.130 GeneticVariation disease GWASDB Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. 18839057 2008
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders 		0.110 Biomarker group BEFREE And, MEF2D and ASTN2 also served as genetic risk factors for the migraine without family history. 28058730 2017