|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
While their accuracy has to be carefully discussed, they can improve the understanding of DBS effects and can be of use for other DBS targets in the therapy of neurological or psychiatric disorders as well.
|
27981031 |
2017 |
|
Absence of sensation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here, we present the comparative research of neuronal activity in subthalamic nucleus (STN) of 8 Parkinsonian patients undergoing DBS surgery in awake state and under propofol anaesthesia using different statistical approaches.
|
30121284 |
2019 |
|
African Trypanosomiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>Trypanosoma brucei</i> causes African trypanosomiasis and contains three full-length oligosaccharyltransferase (OST) genes; two of which, <i>Tb</i>STT3A and <i>Tb</i>STT3B, are expressed in the bloodstream form of the parasite.
|
28928222 |
2017 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, whether DBS could improve sensory memory functions in patients with AD is not clear.
|
29055119 |
2020 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further, we found neuron or glia-specific associations with AD Braak stage progression at genes such as MCF2L, ANK1, MAP2, LRRC8B, STK32C and S100B.
|
30045751 |
2018 |
|
Anhedonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anhedonia reduction observed during the first 30days after initiating the stimulation persisted in the assessment six months after implantation of the DBS.
|
28320164 |
2017 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The presence of MCF2L in human atherosclerotic plaque specimen lends further support to its potential role in atherosclerosis.
|
25898923 |
2016 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The presence of MCF2L in human atherosclerotic plaque specimen lends further support to its potential role in atherosclerosis.
|
25898923 |
2016 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings are thought to be useful for understanding pathological conditions related to DBS such as cancer and non-syndromic autism in future.
|
31089935 |
2019 |
|
bilateral breast cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Considering that Pol θ is involved in DBS repair, our results suggest that this polymorphism may contribute to the etiology of HBC, particularly in patients with bilateral breast cancer.
|
25409685 |
2014 |
|
Bipolar II disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Long-term outcome data were collected for 28 patients (20 with major depressive disorder and seven with bipolar II disorder; one patient in the major depression subgroup was later reclassified as having bipolar II disorder) receiving SCC DBS for 4-8 years.
|
31581800 |
2019 |
|
Blepharospasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, DBS for PD can cause dystonia such as blepharospasm and bilateral pallidal DBS for dystonia can result in features of parkinsonism.
|
31078682 |
2019 |
|
Blood spots
|
0.060 |
Biomarker
|
disease |
BEFREE |
A test based on viral DNA extraction from neonatal dried blood spots on Guthrie cards and its amplification by means of a nested PCR (DBS test) seems to offer the best characteristics for use in screening.
|
16384745 |
2006 |
|
Blood spots
|
0.060 |
Biomarker
|
disease |
BEFREE |
Moreover, we investigated whether dried plasma and blood spots (DPS and DBS, respectively) give comparable viral load (VL) results.
|
19193835 |
2009 |
|
Blood spots
|
0.060 |
Biomarker
|
disease |
BEFREE |
Detection of viral DNA in dried blood spots using the Guthrie card (DBS test) is a reliable and practical method of diagnosing congenital cytomegalovirus (CMV) infection.
|
15135749 |
2004 |
|
Blood spots
|
0.060 |
Biomarker
|
disease |
BEFREE |
Quantification methods were developed and validated using liquid chromatography-tandem mass spectrometry to analyze albendazole and its metabolites albendazole sulfoxide and albendazole sulfone in wet samples (plasma and blood) and blood microsamples (dried-blood spots [DBS]; Mitra).
|
30745388 |
2019 |
|
Blood spots
|
0.060 |
Biomarker
|
disease |
BEFREE |
Resultant dried blood spots may be employed for DNA extraction using a variety of technologies for nucleic acid amplification without the need for repeated cleaning of scissors or punches to prevent cross contamination of samples and results are comparable to traditional DBS.
|
25652763 |
2015 |
|
Blood spots
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Dried spots on filter paper made of whole blood (dried blood spots; DBS), plasma (dried plasma spots; DPS) or serum (dried serum spots) hold promise as an affordable and practical alternative specimen source to liquid plasma for HIV type-1 (HIV-1) viral load determination and drug resistance genotyping in the context of the rapidly expanding access to antiretroviral therapy (ART) for HIV-1-infected individuals in low- and middle-income countries.
|
19704164 |
2009 |
|
Bradykinesia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Whilst changes in the frequency of subthalamic deep brain stimulation (STN-DBS) have been proposed to improve control of tremor or axial motor features in Parkinson's disease (PD), little is known about the effects of frequency changes on upper limb motor function, particularly bradykinesia.
|
29614696 |
2018 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration.
|
19366686 |
2009 |
|
Camptocormia
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the efficacy of DBS for camptocormia varies.
|
28157107 |
2017 |
|
Capillary malformation (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
The subanalysis of patients with CMC (n = 23) and PS (n = 5) showed a 42.7% improvement in abnormal posture severity when considering the independent effect of STN-DBS (P < .001) and 30.5% when considering the combined effect of STN-DBS and levodopa (P < .001).
|
29285760 |
2018 |
|
Cardiovascular Diseases
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Cardiovascular Diseases
|
0.110 |
GeneticVariation
|
group |
BEFREE |
In conclusion, a rare functional variant in MCF2L, leading to impaired DH function, was identified in a small pedigree with premature CVD.
|
25898923 |
2016 |
|
Cerebral Palsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
For the future, well-conducted trials as well as data collection in the international registry is of major importance to increase knowledge about DBS in CP patients, especially those implanted at a young age.
|
27289260 |
2017 |