SYNM, synemin, 23336

N. diseases: 93; N. variants: 1
Disease: Lewy Body Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0752347
Disease: Lewy Body Disease
Lewy Body Disease 		0.020 Biomarker disease BEFREE α-SYN is the main component of round intracytoplasmic inclusions called Lewy bodies (LBs), which are the hallmark of PD and DLB. 29246765 2018
CUI: C0752347
Disease: Lewy Body Disease
Lewy Body Disease 		0.020 Biomarker disease BEFREE Recent studies are now indicating that ɑ-SYN may act in a way similar to prions and that ɑ-SYN misfolded structural variants may behave as strains with distinct biochemical and functional properties inducing specific phenotypic traits, which might finally provide an explanation for the clinical heterogeneity observed between Parkinson's disease, MSA, and dementia with Lewy bodies patients. 26924014 2016