|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the healthy brain, SYN and TPPP/p25 occur in neurons and oligodendrocytes, respectively; however, in PD and multiple system atrophy, they are co-enriched and co-localized in both cell types, thereby marking pathogenesis.
|
31148150 |
2019 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
α-SYN is the main component of round intracytoplasmic inclusions called Lewy bodies (LBs), which are the hallmark of PD and DLB.
|
29246765 |
2018 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We then present preclinical and clinical data that introduce new concepts, such as the use of biased and partial agonists, as well as molecules recently introduced to the field of PD, such as eltoprazine, pimavanserin, nelotanserin, and SYN-120, to enhance therapeutic benefit while minimizing adverse events, notably on parkinsonian disability.
|
28460160 |
2017 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The hallmarks of Parkinson's disease and other synucleinopathies, Tubulin Polymerization Promoting Protein (TPPP/p25) and α-synuclein (SYN) have two key features: they are disordered and co-enriched/co-localized in brain inclusions.
|
27671864 |
2017 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accumulation of α‑synuclein (α‑SYN) is a common pathology for Parkinson's disease (PD).
|
28990084 |
2017 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies are now indicating that ɑ-SYN may act in a way similar to prions and that ɑ-SYN misfolded structural variants may behave as strains with distinct biochemical and functional properties inducing specific phenotypic traits, which might finally provide an explanation for the clinical heterogeneity observed between Parkinson's disease, MSA, and dementia with Lewy bodies patients.
|
26924014 |
2016 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alpha synuclein (SYN) is a central player in the pathogenesis of sporadic and familial Parkinson's disease (PD).
|
23223297 |
2012 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Familial PD with SYN gene mutations are rare because the majority of PD is sporadic and emerging evidence indicates that sporadic PD may result from genetic and environmental risk factors including neuroinflammation.
|
18650345 |
2008 |
|
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To examine the relationship between alpha-SYN, microglial activation, and adaptive immunity, we used a mouse model of Parkinson disease in which human alpha-SYN is overexpressed by a recombinant adeno-associated virus vector, serotype 2 (AAV2-SYN); this overexpression leads to slow degeneration of dopaminergic neurons.
|
19018246 |
2008 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have investigated the effect of UPS inhibition on the metabolism of alpha-synuclein (SYN) and parkin, two proteins genetically and histopathologically associated to PD.
|
14720204 |
2004 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
alpha-Synuclein (alpha-SYN) is deposited in intraneuronal cytoplasmic inclusions (Lewy bodies, LBs) characteristic for Parkinson's disease (PD) and LB dementias. alpha-SYN forms LB-like fibrils in vitro, in contrast to its homologue beta-SYN.
|
11733371 |
2001 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The two Parkinson's disease-associated mutations accelerated the intrinsic aggregation property of alpha-SYN in vitro.
|
11193173 |
2000 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
SYN + AD had similar severity and distribution of neocortical Aβ compared to AD (F<sub>1, 40-43</sub> = 1.6-2.0, p > 0.1).
|
30549331 |
2019 |
|
Alzheimer's Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Our findings indicate a possible relationship between systemic inflammation with DMN FC disruption, hippocampal atrophy, and CSF protein levels in the subjects with mild AD and aMCI.
|
29039020 |
2018 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
CSF t-tau/Aβ<sub>1-42</sub> ratio had 100% specificity and 90% sensitivity for SYN + AD, and CSF Aβ<sub>1-42</sub> had 77% specificity and 82% sensitivity for neocortical SYN stage.
|
29467305 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Expression of neuroendocrine markers (CD56, CGA, and SYN) was not significantly different by tumor location but central tumors had higher serum levels of NSE (p = 0.004).
|
29413048 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Because modest nuclear enlargement of kidney tubule cells can occur as physiological or functional responses, it is recommended that the threshold for diagnosing renal tubule karyomegaly in animal studies should be accepted as at least four times normal nuclear size or larger.Abbreviations: BEN: Balkan Endemic Nephropathy; DMN: dimethylnitrosamine; GLP: Good Laboratory Practice; KIN: karyomegalic interstitial nephritis; LAL: lysinoalanine; MeCCNU: 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea; NTP: National Toxicology Program; OSOM: outer stripe of outer medulla; OTA: ochratoxin A; RTT: renal tubule tumor.
|
30277423 |
2018 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Decreased FC was detected in posterior DMN in the AD group and in the Salience network in the bvFTD group after combining CV quality control with gmICA.
|
28119587 |
2016 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Reduced SYN is associated with AD neuropathology and with Aβ levels in DS, as is seen in sporadic AD.
|
24927707 |
2014 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
It plays a role in human muscle diseases; however, the role of synemin in tumor cell transformation has rarely been investigated.
|
21144834 |
2011 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
SYNM promoter methylation may become a useful predictive biomarker to stratify breast cancer patients' risk for tumor relapse.
|
20543860 |
2010 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
In PCCs, all 28 tumors were immunoreactive for poly Sia and SYN; CrgA was detectable in 26 of 28 (93%), CT was detectable in 6 of 28 (21%), and SOM was detectable in 2 of 28 (7%) tumors.
|
7723281 |
1995 |
|
Schizophrenia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Moreover, HAR and DMN genes show significant associations with individual variations in DMN functional activity, intelligence, sociability, and mental conditions such as schizophrenia and autism.
|
31649260 |
2019 |
|
Mild cognitive disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
Graph theory revealed that changes in the MCI group was mostly restricted to diminished between-neighbour connections of the hippocampi and of nodes within DMN-a and DMN-b.
|
31581245 |
2019 |
|
Mild cognitive disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
MCI surgery had greater functional connectivity decline in DMN and SN.
|
31104019 |
2019 |