Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 GeneticVariation disease GWASCAT Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 GeneticVariation disease BEFREE Our findings link genetic variation in the CPG2 region of SYNE1 with a mechanism for glutamatergic synapse dysfunction that could underlie susceptibility to BD in some individuals. 30610203 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 GeneticVariation disease GWASCAT A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder. 28115744 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 GeneticVariation disease GWASCAT Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. 28072414 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 GeneticVariation disease BEFREE Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder. 28178086 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 GeneticVariation disease BEFREE In conclusion, polymorphisms in CACNA1C and SYNE1 could confer a greater risk of developing SZ and BD in individuals who are already at high risk because of their family history. 27620326 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 Biomarker disease PSYGENET The findings presented here show support for a number of genes previously implicated genes in the etiology of BD, including CSMD1 and SYNE1, as well as evidence for previously unreported genes such as the brain-expressed genes ADCY2, NCALD, WDR60, SCN7A and SPAG16. 24387768 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 Biomarker disease BEFREE Although no genome-wide significant markers were identified, the combined GWAS findings have pointed to several genes of interest that support GWAS findings for BD from other groups or consortia, such as at SYNE1 on 6q25, PPP2R2C on 4p16.1, ZNF659 on 3p24.3, CNTNAP5 (2q14.3), and CDH13 (16q23.3). 24387768 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 Biomarker disease PSYGENET In a sample of 517 individuals (N=121 BD cases, 116 SZ cases, 61 other psychosis cases and 219 healthy controls), we tested the potential association between nine SNPs in the genes CACNA1C, ANK3, ODZ4 and SYNE1 and eight brain structural measures found to be altered in BD, and if these were specifically affecting the BD sample. 23820096 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 GeneticVariation disease GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 GeneticVariation disease GWASDB Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. 23070075 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 Biomarker disease PSYGENET The Psychiatric Genome-Wide Association Study (GWAS) Consortium Bipolar Disorder Working Group (PGC-BD) meta-analysis of BD GWAS data sets and replication samples identified evidence (P=6.7 × 10⁻⁷, odds ratio (OR)=1.147) of association with the risk of BD at the polymorphism rs9371601 within SYNE1, a gene which encodes nesprin-1. 22565781 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 GeneticVariation disease BEFREE The Psychiatric Genome-Wide Association Study (GWAS) Consortium Bipolar Disorder Working Group (PGC-BD) meta-analysis of BD GWAS data sets and replication samples identified evidence (P=6.7 × 10⁻⁷, odds ratio (OR)=1.147) of association with the risk of BD at the polymorphism rs9371601 within SYNE1, a gene which encodes nesprin-1. 22565781 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 GeneticVariation disease GWASCAT Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. 21926972 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 GeneticVariation disease GWASCAT Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. 20351715 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.450 GeneticVariation disease GWASDB Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. 21926972 2011