FN1, fibronectin 1, 2335

N. diseases: 724; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group BEFREE Negative E-∕P-cadherin and positive fibronectin immunophenotype may be associated with aggressive gastric carcinomas and supports the EMT involvement in gastric carcinogenesis. 31658331 2019
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group BEFREE Given the roles of fibronectin in risk stratification and in the frontline therapeutics of common carcinomas, such as renal cell cancer, we explored fibronectin immunoexpression status and its associations with clinicopathological variables and survival in a well-defined cohort of NPC patients. 24081675 2014
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 AlteredExpression group BEFREE Differences in both fibronectin and MUC1 expression between the follicular carcinomas and the follicular adenomas were also significant (P = .025 and .045, respectively). 18094649 2008
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 AlteredExpression group BEFREE The matrix glycoprotein fibronectin, for example, is highly expressed in chronic lung disorders where most lung carcinomas are identified. 19396378 2008
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 AlteredExpression group BEFREE Although up-regulation of FN has been noted in gene profiles of carcinomas compared with normal tissue, reduced FN expression has been described at the peripheral margins of invading tumors. 18829569 2008
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group BEFREE Molecular basis for the presence of glycosylated onco-foetal fibronectin in oral carcinomas: the production of glycosylated onco-foetal fibronectin by carcinoma cells. 16857413 2007
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group BEFREE Only 5 genes were overexpressed in all carcinomas including fibronectin 1 (FN1), tissue metalloproteinase inhibitor 1 (TIMP1), biglycan (BGN), tenascin-C (HXB), and insulin-like growth factor binding protein 5 (IGFBP5), whereas 16 genes were underexpressed. 15642389 2005
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group CTD_human cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene. 12376462 2002
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group BEFREE Distribution of integrins, laminin, type IV collagen, tenascin, and fibronectin was immunohistochemically evaluated in 13 supraglottis carcinomas. 10585605 2000
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 AlteredExpression group BEFREE Therefore, the much increased expression of oncofetal fibronectin mRNA in these carcinomas is not caused by the alternation in splicing, but may be caused by an increase in promoter activity or stability of mRNA of the fibronectin gene. 10090132 1999
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group BEFREE Initial results suggest a correlation between the amount of ED-B+ and de novo-glycosylated fibronectin in tumour stroma and the behaviour of carcinomas with regard to their invasiveness and propensity for metastatic dissemination. 8982375 1996
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group BEFREE These results demonstrate that accumulation of FN adjacent to oral carcinomas includes both the ED-B-containing isoform and the isoform derived by O-glycosylation. 7946273 1994
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 AlteredExpression group BEFREE Study of fibronectin and mRNA in human laryngeal and ectocervical carcinomas by in situ hybridization and image analysis. 1612776 1992