|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In brief, this study has verified that miR-1-3p blocked the EMT process of RCC cells by reducing Fibronectin 1 expression. miR-1-3p/Fibronectin 1 axis may be considered as a new target for drug development of RCC.
|
31417307 |
2019 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
These findings highlight the role of fibronectin in RCC cell growth and migration involving Src and TGF-β1 signaling.
|
31181623 |
2019 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We found fibronectin (FN1) expression was a predictive biomarker in some patients with chemotherapy-resistant RCC, which especially correlated with two starvation-resistant RCC cell lines.
|
31774870 |
2019 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Downregulation of TG2 expression led up to a 60% decrease in actin stress fiber formation and adhesion to β 1 integrin (ITGB1) substrates fibronectin, collagen type I and laminin in both primary and metastatic site RCC cell lines.
|
28498731 |
2018 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Furthermore, the chromatin immunoprecipitation assay indicated that pCREB (Ser133) had a direct interaction with the fibronectin promoter, however, pCREB (Ser133) did not target the vimentin promoter in RCC.
|
28487942 |
2017 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Given the roles of fibronectin in risk stratification and in the frontline therapeutics of common carcinomas, such as renal cell cancer, we explored fibronectin immunoexpression status and its associations with clinicopathological variables and survival in a well-defined cohort of NPC patients.
|
24081675 |
2014 |
|
Renal Cell Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
RCC(res) detached from fibronectin and motile activity further increased under retreatment with low-dosed temsirolimus.
|
24862756 |
2014 |
|
Renal Cell Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
This mechanism is clinically significant, because primary cancer cells from patients with metastatic RCC strongly invaded fibrin and this correlated with fibronectin matrix formation and Slug expression.
|
23966293 |
2013 |
|
Renal Cell Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Mean tissue specific FN1 mRNA expression was found to be increased approximately seven fold comparing RCC and corresponding kidney control tissues (p < 0.001; ANOVA).
|
20860816 |
2010 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
These two cRCC showed a tumor cell-negative and stroma-positive pattern of Fn staining.
|
15262424 |
2004 |
|
Renal Cell Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
To understand further if cytokine-gene transfection of RCC could alter certain cellular properties that are associated with the invasive and metastatic potentials of tumor, the authors characterized six cell lines that produce IL-2 and/or IFN-alpha in their expression of intercellular adhesion molecule-1 (ICAM-1) and CD44; binding affinity to extracellular matrix (ECM) components (fibronectin, laminin, type IV collagen, and vitronectin); and preference in forming homotypic aggregation and mRNA levels of c-myc, epidermal growth factor receptor (EGF-R), tumor transforming growth factor-beta (TGF-beta) and type IV collagenase.
|
7521786 |
1994 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Truncated fibronectin. An autologous growth-promoting substance secreted by renal carcinoma cells.
|
1348659 |
1992 |
|
Renal Cell Carcinoma
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|