|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fibronectin 1 promotes melanoma proliferation and metastasis by inhibiting apoptosis and regulating EMT.
|
31118673 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Its re-expression inhibited melanoma growth and metastasis and reduced the deposition of fibronectin, a major ECM component.
|
29450192 |
2018 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Rebuilding of melanoma into the fibrous tissue during SR was connected with a general rise in fibronectin and tenascin C expression.
|
30061229 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fibronectin is a large multidomain protein of the extracellular matrix that harbors two heparin binding sites, Hep-I and Hep-II, which support the heparin-dependent adhesion of melanoma and neuroblastoma cells [Barkalow, F. J.
|
30260627 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human melanoma inhibitory protein binds to the FN12-14 Hep II domain of fibronectin.
|
28565914 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BCP inhibited integrin-mediated adhesion of human melanoma A375 cells to fibronectin but had no effects on nonspecific adhesion to poly-l-lysine.
|
27842819 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Analysis of a melanoma tissue microarray showed loss of PTEN expression to predict for a lower overall survival, with a trend for even lower survival being seen when loss of fibronectin was included in the analysis.
|
26073081 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whereas the role of TNC (tenascin C) and FN1 (fibronectin 1) in melanoma development is well documented, implication of MARCKS, RCN3, BAMBI, PEA3/ETV4 and the FK506 family members FKBP7, FKBP10 and FKBP11 in melanoma progression is unclear.
|
27689402 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Melanoma cell adhesion to fibronectin in the presence of Sambucus nigra agglutinin (SNA) was reduced only in IGR-39 and WM266-4 cells, whereas the impact of Maackia amurensis agglutinin (MAA) on this process was much more important.
|
27474400 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we report a novel mechanism through which NME1 controls melanoma cell morphology via upregulation of the extracellular matrix (ECM) protein fibronectin.
|
25808322 |
2015 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Forced NME1 expression in a variety of melanoma-derived cell lines was shown to induce dynamic changes in cell morphology and reorganization of the actin cytoskeleton, with formation of a network of thick stress fibers and assembly of fibronectin fibrils at large focal adhesions.
|
25017017 |
2015 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CH50, a recombinant CBD-HepII polypeptide of human fibronectin, was shown to suppress tumor metastasis in murine hepatocarcinoma and melanoma models.
|
24288120 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we showed that lipid rafts played a critical role in human melanoma A375 cell spreading and migration on fibronectin; an important component of the ECM that interacts with β1 integrin.
|
24292944 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Of the genes identified, seven genes: galectin 3 (Lgals3), melanoma cell adhesion molecule (Mcam), fibronectin 1 (Fn1), signal transducer and activator of transcription 3 (Stat3), microphthalmia-associated transcription factor (Mitf), max interacting protein 1 (Max1), and non-metastatic cells 1, protein (NM23A) expressed in (Nme1) are known to be associated with melanoma, but have not yet been reported as being regulated by hypoxia in human melanoma cells.
|
21912348 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The reduced ability of M5 cells to adhere onto the fibronectin (FN) substrate was directly correlated to a decrease in the expression of focal adhesion kinase (FAK), which is a key regulator of melanoma motility.
|
21360640 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these data support the notion that BH3 mimetic compounds that target Mcl-1 may be effective for the treatment of melanoma in combinatorial strategies with agents that disrupt fibronectin-integrin signaling.
|
19372583 |
2009 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The reduction in syndecan-4 expression by utilizing specific siRNA discriminately increased melanoma cell motility and decreased their attachment on FN, demonstrating a regulatory role of syndecan-4 on these cell functions.
|
19110070 |
2009 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most importantly, siRNA-downregulation of hB7H3 reduced cell adhesion to fibronectin of melanoma and breast cancer cells by up to 50 %, and migration and matrigel-invasion by more than 70 %, but surprisingly had no apparent impact on cell proliferation.
|
18690846 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results reveal a tumor-specific regulation of fibronectin by constitutive ERK/MAP kinase signaling and indicate that self-production of fibronectin may play a role in melanoma tumorigenesis, by promoting tumor cell invasion.
|
16960555 |
2007 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Secreted trbeta3 inhibited adhesion of melanoma and prostate cancer cells to fibronectin and vitronectin, which was partially reversed by adsorption of trbeta3 from the media.
|
17912026 |
2007 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our DNA microarray analyses of benign nevi and melanoma tissue specimens revealed that the genes encoding extracellular matrix proteins tenascin-C (TN-C), fibronectin (FN), and procollagen-I (PCOL-I) are highly upregulated in invasive and metastatic melanomas.
|
16924594 |
2006 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Role of the extracellular matrix proteins in the resistance of SP6.5 uveal melanoma cells toward cisplatin.
|
15645125 |
2005 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased fibronectin synthesis has been associated with the metastatic potential of melanoma cells; however, the molecular mechanisms underlying fibronectin overexpression during melanoma development are poorly understood.
|
15608673 |
2005 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The purpose of the present study was to investigate the expression of integrin subunit alpha5, its corresponding ligand fibronectin (FN), and the expression pattern for MMPs in four highly proliferative human choroidal melanomas (TP17, TP31, SP8.0, and SP6.5) to evaluate whether any correlation can be established between these markers and cell tumorigenicity.
|
10892885 |
2000 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that FN is able to modulate expression and secretion of a defined subset of lymphokines in human melanoma.
|
8608953 |
1996 |