|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Some ECM-related genes were significantly different in the tumor group, including collagen types I, III, IV, V, and VI, non-collagenous glycoproteins, laminin, and fibronectin.
|
31629818 |
2020 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The fusion protein bound avidly to the cognate antigen (the alternatively spliced EDB domain of fibronectin), retained the activity of the parental cytokine and was able to selectively localize to murine tumors in vivo, as shown by quantitative biodistribution analysis.
|
31374124 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Parallel studies in a xenograft tumor mice model further showed that tumor growth correlated well with elevation of circulating fibronectin and activation of the identified intracellular signaling molecules.
|
30551431 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In vivo experiment demonstrated that FN1 knockdown significantly inhibited FN1 expression, phosphorylation of FAK, and tumor growth in xenograft from the nude mice.
|
30977220 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A novel near-infrared fluorescent light-up probe with a tumor-homing pentapeptide, CREKA (Cys-Arg-Glu-Lys-Ala), specifically binds to fibrin-fibronectin complexes was rationally designed and developed for biomedical imaging.
|
30742156 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The F8 antibody recognizes the alternatively-spliced ED-A domain of fibronectin, an extracellular matrix component found in most tumor types, while calreticulin has previously been described as an "eat-me" signal for dendritic cells and phagocytes.
|
30579890 |
2019 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Furthermore, silencing of FN1 could stimulate the tumour suppressor effects of miR-432 upregulation in cervical cancer cells.
|
31423213 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The data support continued optimization of the new class of SMIs that block the TG2/FN complex at the interface between cancer cells and the tumor niche.
|
31015308 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Compared to the low FN1 expression group, the high FN1 expression group had significantly larger tumor size (P = 0.002), more advanced T stage (P = 0.039) and N stage (P = 0.009), and also worse AJCC stage (P = 0.003).
|
30736807 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The distribution and content of fibronectin is closely related to the occurrence and development of tumors.
|
31530096 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It is also shown that CREKA (Cys-Arg-Glu-Lys-Ala), a tumor-homing pentapeptide, targets fibrin-fibronectin complexes that are found on the tumor stroma and the vessel walls.
|
31429535 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CAR T cells that target the tumor stroma and vasculature through the EIIIB<sup>+</sup> fibronectin splice variant, which is expressed by multiple tumor types and on neovasculature, are likewise effective in delaying tumor growth.
|
30936321 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tenascin C, Fibronectin, and Tumor-Stroma Ratio in Pancreatic Ductal Adenocarcinoma.
|
30451798 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
During the analysis of data, key molecules (brevican, cadherin-12, fibronectin and integrin-β1) correlating the most with tumor grade were selected.
|
28161812 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, mesenchymal tumor cells do not produce a FN matrix and cannot complete the metastatic process, even when grown within a tumor containing epithelial cells.
|
29934326 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immediately after surgery, a tumor fragment from a minor salivary gland from the tongue of a female Caucasian was minced, dissociated, and a single cell suspension was plated in fibronectin-coated flasks.
|
30527239 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We describe the comparative X-ray structural analysis of three Anticalin proteins directed against the extra-domain B (ED-B) of oncofetal fibronectin (Fn), a validated marker of tumor neoangiogenesis.
|
29526433 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In MSRs, different immunophenotypes were distributed rather equally (Ten<sup>+</sup>Fn<sup>+</sup>Gal-1<sup>+</sup>=24%; Ten<sup>-</sup>Fn<sup>+</sup>Gal-1<sup>-</sup>=36%; Ten<sup>-</sup>Fn<sup>-</sup>Gal-1<sup>-</sup>=33%), differing to the results in tumors (p<0.05).
|
29491051 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FN expression in ESCC specimens was mainly detected in the tumor stroma, with very little FN detected in tumor cells.
|
30314454 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NKp46- and Ncr1-mediated IFN-γ production led to the increased expression of the extracellular matrix protein fibronectin 1 (FN1) in the tumors, which altered primary tumor architecture and resulted in decreased metastases formation.
|
29329948 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Patients with p16 positive tumors or tumors with a low intensity of fibronectin showed significantly higher overall survival in univariable regression.
|
30571736 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Complexes formed by TG2, fibronectin (FN), and integrin β1 were enriched in ovarian CSC and detectable in tumors.
|
29510995 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Fibronectin and its complexes are expressed on the walls of tumor vessels and in tumor stroma.
|
29277681 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We aimed to analyze whether initial tumor tissue expressions of survivin, p53, cyclin D1, osteopontin (OPN) and fibronectin (FN) correlate with the response to neo-adjuvant CHT (naCHT) in children with advanced inoperable MPNST.
|
29332262 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of collagens, fibronectin and laminins was significantly increased in esophageal squamous cell carcinomas (ESCC) tumor samples compared to the corresponding normal tissue.
|
30241395 |
2018 |