SIRT3, sirtuin 3, 23410

N. diseases: 227; N. variants: 11
Disease: Gestational Diabetes ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.310 Biomarker phenotype BEFREE In conclusion, our findings support a model where Sirt3 plays a protective role against oxidative stress in oocytes exposed to maternal diabetes through deacetylating SOD2K68. 28662362 2017
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.310 Biomarker phenotype CTD_human Importantly, acetylation of MnSOD, a SIRT3 target, was increased in obese-NGT and obese-GDM vs NW women and was inversely correlated with SIRT3 activity (r = -0.603), suggesting a mechanism for reduced MnSOD activity. 23956348 2013