SIRT3, sirtuin 3, 23410

N. diseases: 227; N. variants: 11
Disease: Colon Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.040 Biomarker disease BEFREE In conclusion, SIRT3 could be a target for colon cancer, since it regulates the antioxidant response and its knockdown improves the efficacy of oxaliplatin treatment. 29323702 2018
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.040 AlteredExpression disease BEFREE However, significant relationship between SIRT3 expression and OS in specific cancers was detected, including chronic lymphocytic leukemia (CLL) (HR=0.48, 95% CI=0.26-0.89, <i>P</i>=0.019), hepatocellular carcinoma (HCC) (HR=0.56, 95% CI=0.42-0.74, <i>P</i><0.001), pancreatic carcinoma (PC) (HR=0.55, 95% CI=0.30-1.00, <i>P</i>=0.049), renal cell carcinoma (RCC) (HR=0.13, 95% CI=0.02-0.98, <i>P</i>=0.048), breast cancer (BC) (HR=2.53, 95% CI=1.83-3.67, <i>P</i><0.001), colon cancer (CC) (HR=1.87, 95% CI=1.12-3.26, <i>P</i>=0.022) and non-small-cell lung cancer (NSCLC) (HR=2.20, 95% CI=1.38-3.50, <i>P</i>=0.001). 29713184 2018
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.040 Biomarker disease BEFREE The energy reprogramming effects of GAD on colon cancer seem to be mediated by SIRT3 upregulation via acetylated CypD inhibition. 29374515 2018
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.040 AlteredExpression disease BEFREE Here, we demonstrate that SIRT3 expression is induced in an array of radiation-treated human tumor cells and their corresponding xenograft tumors, including colon cancer HCT-116, glioblastoma U87, and breast cancer MDA-MB231 cells. 26141949 2015