SIRT3, sirtuin 3, 23410

N. diseases: 227; N. variants: 11
Disease: ovarian neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 Biomarker disease BEFREE Development and validation of SIRT3-related nomogram predictive of overall survival in patients with serous ovarian cancer. 31113446 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 Biomarker disease BEFREE We highlight a "mitochondrial signature" in OC that could result from cooperation of the cAMP pathway with the SIRT3, OPA1, and PHB2 proteins. 31547300 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 Biomarker disease BEFREE In conclusion, our results demonstrated that SIRT3 plays a crucial suppressive role in the metastasis of ovarian cancer by down-regulating Twist, and that this novel SIRT3/Twist axis may be valuable to develop new strategies for treating OC patients with metastasis. 27216459 2016
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 Biomarker disease BEFREE This study underscores an essential role of SIRT3 in the antitumor effect of Bcl-2 inhibitors in human ovarian cancer through regulating both metabolism and apoptosis. 27277143 2016