|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In both models we show that c-MYC and SIRT1 protein expression increased through progression from hyperplasia to invasive carcinomas and metastases.
|
31442917 |
2019 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SIRT1 upregulation has already been demonstrated in some cancer cells, such as acute myeloid leukemia (AML) and primary colon, prostate, melanoma, and non-melanoma skin cancers, while SIRT1 downregulation was described in breast cancer and hepatic cell carcinomas.
|
31261609 |
2019 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, Sirt1 overexpression in mice delays the appearance of K-Ras<sup>G12V</sup>-driven lung adenocarcinomas, reducing the number and size of carcinomas at the time of death and extending survival.
|
30021836 |
2018 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Also, according to this fact that carcinomas as the main human solid tumors, originate from different epithelial cell types, SIRT1 role in EMT has received a great attention due to its potential role in tumor development and metastasis.
|
29194618 |
2018 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Although many studies have discussed the association of abnormally expressed silent information regulator 1 (Sirt1) with the prognosis of patients with a variety of solid carcinomas, they failed to agree on whether excessive Sirt1 indicates a good or poor overall survival for the patients.
|
29029516 |
2017 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of SIRT1 was higher in endometrioid, mucinous, and clear-cell carcinomas than in the inclusion cysts of normal ovaries, but not in serous carcinoma (P=0.038).
|
26862948 |
2017 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SIRT1 expression was significantly higher in poorly differentiated carcinomas.
|
24088390 |
2013 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas.
|
24019980 |
2013 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, approximately 30% of carcinomas showed lower than normal SirT1 expression.
|
19433578 |
2009 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Of twenty gastric carcinomas examined, 13 (65%), 14 (70%), 16 (80%), 12 (60%) and 13 (65%) expressed MRE11, RAD50, NBS1, Sir2 and hRap1 at higher levels than corresponding nonneoplastic gastric mucosa, respectively.
|
12007281 |
2001 |