SIRT1, sirtuin 1, 23411

N. diseases: 675; N. variants: 21
Disease: Lung Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.030 Biomarker group BEFREE Our results show that SIRT1 facilitates endothelial cell branching and proliferation to increase vessel density and promote lung tumor growth through down-regulation of DLL4/Notch signaling and deacetylation of N1IC. 23028940 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.030 AlteredExpression group BEFREE Decreased activity of SIRT1 was validated using genomic analyses of mouse models of lung cancer and biochemical testing of SIRT1 activity in patient lung tumors. 22986747 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.030 AlteredExpression group LHGDN Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. 17624472 2007