|
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of miR-34a inhibits the activity of SIRT1, thereby promoting the apoptosis of MI.
|
31486508 |
2019 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
LncRNA KLF3-AS1 in exosomes secreted from hMSCs by acting as a ceRNA to sponge miR-138-5p can regulate Sirt1 so as to inhibit cell pyroptosis and attenuate MI progression.
|
31847890 |
2019 |
|
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In MI+STNx groups, SIRT1 knockout led to more severe cardiac structural and functional deterioration, with higher Masson-staining score and BNP levels, and lower EF, FS, Max +dp/dt, and Max -dp/dt values; while SIRT1 overexpression had the opposite attenuating effects.
|
29566363 |
2018 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
We found that FP treatment improved heart function, reduced cardiac fibrosis, and downregulated the expression of fibrosis-related factors including collagen I, collagen III, matrix metalloproteinase-2 (MMP-2), MMP-9, transforming growth factor-<i>β</i>1 (TGF-<i>β</i>1), and p-Smad2/3, which coincided with the upregulated expression of silent information regulator 1 (SIRT1) in the hearts of MI rats.
|
30050588 |
2018 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
Conclusions The present study identified Sirt1 antisense lnc RNA as a novel regulator of cardiomyocyte proliferation and cardiac regeneration by interacting and stabilizing Sirt1 mRNA , which may serve as an effective gene target for preventing myocardial infarction.
|
30608184 |
2018 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
The index of low SIRT1 and high MMP2 respectively correlated with patients history of MI (ρ=0.3, p=0.01) and marginally with presence or history of atrial fibrillation (AF) (ρ=0.213, p=0.076).
|
28043667 |
2017 |
|
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, melatonin significantly inhibited Mst1 phosphorylation while promoting Sirt1 expression after MI, which indicates that Mst1/Sirt1 signaling may serve as the downstream target of melatonin.
|
27696525 |
2017 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data identify a previously unrecognized role for SUV39H linking SIRT1 trans-repression to myocardial infarction.
|
28361889 |
2017 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
Therefore, it was hypothesized that SIRT1 might be important in the development of myocardial infarction.
|
28901505 |
2017 |
|
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Here we aimed to investigate the influence of SIRT1 polymorphisms on individual susceptibility to MI.
|
25706717 |
2015 |
|
Myocardial Infarction
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In this study, the SIRT1 gene promoter were genetically analyzed in large cohorts of MI patients (n = 327) and controls (n = 358).
|
22935421 |
2012 |
|
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
RGD |
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.
|
20089851 |
2010 |
|
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, tyrosol induced the expression of longevity protein SIRT1 (3.2-fold) in the MI group as compared to the non-treated MI control.
|
18826227 |
2008 |