SIRT1, sirtuin 1, 23411

N. diseases: 675; N. variants: 21
Disease: polyps ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032584
Disease: polyps
polyps 		0.020 Biomarker phenotype BEFREE In addition, resveratrol (a SIRT1 activator) treatment suppressed nasal polypogenesis in WT mice; however, sirtinol (a SIRT1 inhibitor) administration increased the polyp burden in SIRT1 transgenic mice. 26342525 2016
CUI: C0032584
Disease: polyps
polyps 		0.020 Biomarker phenotype BEFREE We found that SIRT1-inactivation reduced total polyp surface (9.3 mm(2) vs. 23.3 mm(2), p = 0.01), average polyp size (0.24 mm(2) vs. 0.51 mm(2), p = 0.005) and the number of polyps >0.5 mm in diameter (14 vs. 23, p = 0.04), indicating that SIRT1 affects both the number and size of tumors. 23799088 2013