SIRT1, sirtuin 1, 23411

N. diseases: 675; N. variants: 21
Disease: Acute GVH disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease 		0.010 Biomarker disease BEFREE Using major histocompatibility complex (MHC)-mismatched and MHC-matched murine BMT models, we found that Sirt-1<sup>-/-</sup> T cells had a reduced ability to induce acute GVHD (aGVHD) via enhanced p53 acetylation. 30514750 2019