SIRT1, sirtuin 1, 23411

N. diseases: 675; N. variants: 21
Disease: Tauopathies ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.050 Biomarker group BEFREE These results suggest that SIRT1 may serve as a therapeutic target for tauopathy by regulating SC35-mediated tau exon 10 splicing. 29226865 2018
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.050 Biomarker group BEFREE These findings suggest that Sirt1 may serve as a new drug target for Alzheimer's Disease related tauopathies and resveratrol may be used to correct dysregulated tau exon 10 with 3R-tau > 4R-tau. 30243024 2018
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.050 Biomarker group BEFREE SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy. 29540553 2018
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.050 AlteredExpression group BEFREE A deficiency in SirT1 level has been recently implicated in increased tau acetylation, a dominant post-translational modification and key pathological event in AD and tauopathies. 30514854 2018
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.050 AlteredExpression group BEFREE Attenuation of β-amyloid-induced tauopathy via activation of CK2α/SIRT1: targeting for cilostazol. 24254769 2014