NCS1, neuronal calcium sensor 1, 23413

N. diseases: 48; N. variants: 2
Disease: Fragile X Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0016667
Disease: Fragile X Syndrome
Fragile X Syndrome 		0.020 Biomarker disease BEFREE The crystal structure of the Drosophila NCS-1/IGS-1.76 complex demonstrates that the new inhibitor, although chemically different from FD44, shares the same mechanism of action and constitutes a new hit candidate for FXS. 29966094 2018
CUI: C0016667
Disease: Fragile X Syndrome
Fragile X Syndrome 		0.020 GeneticVariation disease BEFREE Our study shows the drugability of the NCS-1/Ric8a interface and uncovers a suitable region in NCS-1 for development of additional drugs of potential use on FXS and related synaptic disorders. 28119500 2017