|
Schizophrenia
|
0.340 |
Biomarker
|
disease |
BEFREE |
This review summarizes these functions and relates them to several diseases in which NCS-1 plays a role, such as schizophrenia and bipolar disorder, X-linked mental retardation and fragile X syndrome, and spinal cord injury.
|
30719643 |
2019 |
|
Schizophrenia
|
0.340 |
Biomarker
|
disease |
PSYGENET |
Although NCS-1 has been associated with psychiatric conditions including autism, bipolar disorder and schizophrenia, it is unclear which role NCS-1 plays in behavior.
|
24631552 |
2014 |
|
Schizophrenia
|
0.340 |
Biomarker
|
disease |
BEFREE |
In this review we discuss how the selective targeting of a DRIP, such as NCS-1, can be utilized as a novel strategy of drug design for the creation of new therapeutics for a disease such as schizophrenia.
|
21777187 |
2012 |
|
Schizophrenia
|
0.340 |
Biomarker
|
disease |
PSYGENET |
Up-regulation of calcyon and NCS-1 in the second schizophrenia cohort strengthens the proposition that abnormalities of the dopamine system in this disease may lie in altered levels of dopamine receptor-interacting proteins.
|
15364041 |
2004 |
|
Schizophrenia
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of calcyon and NCS-1 in the second schizophrenia cohort strengthens the proposition that abnormalities of the dopamine system in this disease may lie in altered levels of dopamine receptor-interacting proteins.
|
15364041 |
2004 |
|
Schizophrenia
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that the dorsolateral prefrontal cortex in schizophrenia and bipolar cases from the Stanley Foundation Neuropathology Consortium display significantly elevated levels of the D2 dopamine receptor desensitization regulatory protein, neuronal calcium sensor-1.
|
12496348 |
2003 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
BEFREE |
This review summarizes these functions and relates them to several diseases in which NCS-1 plays a role, such as schizophrenia and bipolar disorder, X-linked mental retardation and fragile X syndrome, and spinal cord injury.
|
30719643 |
2019 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Although NCS-1 has been associated with psychiatric conditions including autism, bipolar disorder and schizophrenia, it is unclear which role NCS-1 plays in behavior.
|
24631552 |
2014 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
BEFREE |
Lithium inhibited the enhancing effect of NCS-1 on InsP3R1 function, suggesting that InsP3R1/NCS-1 interaction is an essential component of the pathomechanism of bipolar disorder.
|
16691292 |
2006 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Lithium inhibited the enhancing effect of NCS-1 on InsP3R1 function, suggesting that InsP3R1/NCS-1 interaction is an essential component of the pathomechanism of bipolar disorder.
|
16691292 |
2006 |
|
Cocaine Dependence
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Our data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of CA in individuals of African descent.
|
22999924 |
2012 |
|
Cocaine Dependence
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of CA in individuals of African descent.
|
22999924 |
2012 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
|
23535033 |
2014 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
|
23535033 |
2014 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
This newly identified association between NCS-1 and basal breast cancers, together with the identification of the role of NCS-1 in the regulation of the effects of doxorubicin in MDA-MB-231 breast cancer cells, suggests that NCS-1 and/or pathways regulated by NCS-1 may be important in the treatment of basal breast cancers in women.
|
31647602 |
2020 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
However, the association between NCS-1 and breast cancer molecular subtypes and the effects of NCS-1 silencing on calcium (Ca<sup>2+</sup> ) signaling in breast cancer cells remain unexplored.
|
31647602 |
2020 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Nude mice were injected with breast cancer cells to monitor NCS1-dependent metastasis formation over time.
|
30592625 |
2019 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Nude mice were injected with breast cancer cells to monitor NCS1-dependent metastasis formation over time.
|
30592625 |
2019 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We recently found that expression of Neuronal Calcium Sensor 1 (NCS1), a Ca2<sup>+</sup>-dependent signaling molecule, predicted disease outcome in breast cancer, but its predictive value in other cancer types is unknown.
|
29789326 |
2018 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Among the diseases that were found to be associated with NCS-1 are neurological disorders such as bipolar disease and non-neurological conditions such as breast cancer.
|
29746899 |
2018 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We recently found that expression of Neuronal Calcium Sensor 1 (NCS1), a Ca2<sup>+</sup>-dependent signaling molecule, predicted disease outcome in breast cancer, but its predictive value in other cancer types is unknown.
|
29789326 |
2018 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Among the diseases that were found to be associated with NCS-1 are neurological disorders such as bipolar disease and non-neurological conditions such as breast cancer.
|
29746899 |
2018 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
These findings indicate that NCS-1 plays a role in the aggressive behavior of a subset of breast cancers and has therapeutic or biomarker potential.<b>Implications:</b> NCS-1, a calcium-binding protein, is associated with clinicopathologic features of aggressiveness in breast cancer cells and worse outcome in two breast cancer patient cohorts.<i></i>.
|
28275088 |
2017 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
These findings indicate that NCS-1 plays a role in the aggressive behavior of a subset of breast cancers and has therapeutic or biomarker potential.<b>Implications:</b> NCS-1, a calcium-binding protein, is associated with clinicopathologic features of aggressiveness in breast cancer cells and worse outcome in two breast cancer patient cohorts.<i></i>.
|
28275088 |
2017 |
|
Autistic Disorder
|
0.040 |
Biomarker
|
disease |
BEFREE |
Defective NCS-1 can be deleterious to cells and has been linked to serious neuronal disorders like autism.
|
30618617 |
2018 |